IL-6 promoter polymorphism - 174G>C and risk of young adult Hodgkin lymphoma in case subjects vs matched control subjects
Genotype . | Case subjects/control subjects . | OR* . | 95% CI . | P . |
|---|---|---|---|---|
| All subjects and controls | ||||
| GG† | 41/25 | 1.00 | — | |
| GC | 37/39 | 0.50 | 0.22-1.13 | .10 |
| CC | 8/14 | 0.29 | 0.10-0.87 | .03 |
| Missing | 2/9 | — | — | — |
| Trend‡ | .01 | |||
| MZ subjects and controls | ||||
| GG† | 30/17 | 1.00 | — | |
| GC | 24/27 | 0.43 | 0.15-1.24 | .12 |
| CC | 5/9 | 0.24 | 0.06-1.05 | .06 |
| Missing | 1/7 | — | — | — |
| Trend‡ | .03 | |||
| DZ subjects and controls | ||||
| GG† | 11/8 | 1.00 | — | — |
| GC | 13/12 | 0.68 | 0.18-2.61 | .57 |
| CC | 3/5 | 0.42 | 0.08-2.18 | .30 |
| Missing | 1/2 | — | — | — |
| Trend‡ | .30 | |||
| NS subjects and controls | ||||
| GG† | 28/15 | 1.00 | — | |
| GC | 25/26 | 0.32 | 0.09-1.09 | .07 |
| CC | 6/10 | 0.19 | 0.04-0.84 | .03 |
| Missing | 1/9 | |||
| Trend‡ | .02 | |||
| Other (non-NS)§ subjects and controls | ||||
| GG† | 11/8 | 1.00 | — | |
| GC | 10/12 | 0.72 | 0.21-2.49 | .60 |
| CC | 2/4 | 0.45 | 0.08-2.59 | .37 |
| Missing | 1/0 | — | — | — |
| Trend‡ | .36 |
Genotype . | Case subjects/control subjects . | OR* . | 95% CI . | P . |
|---|---|---|---|---|
| All subjects and controls | ||||
| GG† | 41/25 | 1.00 | — | |
| GC | 37/39 | 0.50 | 0.22-1.13 | .10 |
| CC | 8/14 | 0.29 | 0.10-0.87 | .03 |
| Missing | 2/9 | — | — | — |
| Trend‡ | .01 | |||
| MZ subjects and controls | ||||
| GG† | 30/17 | 1.00 | — | |
| GC | 24/27 | 0.43 | 0.15-1.24 | .12 |
| CC | 5/9 | 0.24 | 0.06-1.05 | .06 |
| Missing | 1/7 | — | — | — |
| Trend‡ | .03 | |||
| DZ subjects and controls | ||||
| GG† | 11/8 | 1.00 | — | — |
| GC | 13/12 | 0.68 | 0.18-2.61 | .57 |
| CC | 3/5 | 0.42 | 0.08-2.18 | .30 |
| Missing | 1/2 | — | — | — |
| Trend‡ | .30 | |||
| NS subjects and controls | ||||
| GG† | 28/15 | 1.00 | — | |
| GC | 25/26 | 0.32 | 0.09-1.09 | .07 |
| CC | 6/10 | 0.19 | 0.04-0.84 | .03 |
| Missing | 1/9 | |||
| Trend‡ | .02 | |||
| Other (non-NS)§ subjects and controls | ||||
| GG† | 11/8 | 1.00 | — | |
| GC | 10/12 | 0.72 | 0.21-2.49 | .60 |
| CC | 2/4 | 0.45 | 0.08-2.59 | .37 |
| Missing | 1/0 | — | — | — |
| Trend‡ | .36 |
Cl indicates confidence interval; MZ indicates monozygotic; DZ, dizygotic; NS, nodular sclerosis; and —, not applicable or insufficient data.
Odds ratio (OR) was estimated by using multivariate conditional logistic regression, including subjects with missing data using an indicator variable.
Reference genotype.
Linear trend for the effect of the number of C alleles relative to that of G alleles.
This does not include case subjects with missing pathology reports or their matched controls.