Table 4. Mean IL-6 PMBC supernatant... | American Society of Hematology

Table 4.

Mean IL-6 PMBC supernatant levels (pg/mL) in unaffected monozygotic and dizygotic twins and control subjects by -174G>C genotype (n = 115)

	Mean^*IL-6 PBMC supernatant level (pg/m:) by genotype
	GG	GC	CC	P†
Adjusted for ELISA plate	967.9	467.0	356.5	.06
Adjusted for sex and ELISA plate	997.6	789.8	402.5	.06
Adjusted for age‡ and ELISA plate	1023.5	885.8	447.8	.10
Adjusted for age‡ sex, and ELISA plate	1011.9	906.3	455.9	.12

	Mean^*IL-6 PBMC supernatant level (pg/m:) by genotype
	GG	GC	CC	P†
Adjusted for ELISA plate	967.9	467.0	356.5	.06
Adjusted for sex and ELISA plate	997.6	789.8	402.5	.06
Adjusted for age‡ and ELISA plate	1023.5	885.8	447.8	.10
Adjusted for age‡ sex, and ELISA plate	1011.9	906.3	455.9	.12

Geometric mean from log-transformed IL-6 levels.

P was obtained by using ANOVA (SAS GLM procedure) for overall difference in IL-6 PBMC supernatant levels by genotype.

Age is modeled as an 8-level categorical variable (< 25, 25-29, 30-34, 40-44, 45-49, 50-54, and 55+ years).