Table 1. Targeting and base change... | American Society of Hematology

Table 1.

Targeting and base change characteristics of mutations in B-CLL, unmutated B-CLL, and non-B-CLL V_Hgenes

	No. of sequences	No. of mutations	R/S ratio					Germ line RGYW, %	Mutation in RGYW, %	Transitions-to-transversions ratio
Type	No. of sequences	No. of mutations			Total	CDR	FR	Germ line RGYW, %	Mutation in RGYW, %	Transitions-to-transversions ratio
B-CLL	172	1789	2.35^*	4.60^*	1.72^*	25.6	43.9^*	1.294^*
B-CLL with less than 2% mutation	71	71	1.86^*	3.50†	1.40^*	24.7	53.5^*	1.152^*
Non-B-CLL	67	452	2.23	4.27	1.50	24.9	49.1	1.294

	No. of sequences	No. of mutations	R/S ratio					Germ line RGYW, %	Mutation in RGYW, %	Transitions-to-transversions ratio
Type	No. of sequences	No. of mutations			Total	CDR	FR	Germ line RGYW, %	Mutation in RGYW, %	Transitions-to-transversions ratio
B-CLL	172	1789	2.35^*	4.60^*	1.72^*	25.6	43.9^*	1.294^*
B-CLL with less than 2% mutation	71	71	1.86^*	3.50†	1.40^*	24.7	53.5^*	1.152^*
Non-B-CLL	67	452	2.23	4.27	1.50	24.9	49.1	1.294

Not a significant difference compared with non-CLL (P > .4).

Not a significant difference compared with non-CLL (P > .05).