Table 1. Characteristics of... | American Society of Hematology

Table 1.

Characteristics of antigen-induced regulatory T cells

	Means of regulatory T-cell induction
	Trs	Mucosal M-DCs	Cutaneous M-DCs	PDCs	IDCs	Blocking antibodies*	LFA-3	Notch-L	IL10
Phenotype	CD8⁺ CD28^-	CD4⁺ or CD8⁺	CD4⁺ CD25^-	CD8⁺	CD4⁺ or CD8⁺	CD4⁺ CD25^+/-	CD4⁺ CD25⁺	CD4⁺ or CD8⁺	CD4⁺ (Tr1)
MHC restriction	Yes	No	No	No	No	No	No	No	No
Suppression mediator
Cytokines	No	Yes	No	Yes	Yes	Yes	Yes	No	Yes
T cell-T cell interaction	No	?	Yes	No	Yes	?	Yes	Yes	Yes
T cell-APC interaction	Yes	?	Yes	No	Yes	?	?	Yes	?
Antigen specificity	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes
Reference number	29	31, 32, 34	38	27	52-55	23, 26, 43	58	65-67	68

	Means of regulatory T-cell induction
	Trs	Mucosal M-DCs	Cutaneous M-DCs	PDCs	IDCs	Blocking antibodies*	LFA-3	Notch-L	IL10
Phenotype	CD8⁺ CD28^-	CD4⁺ or CD8⁺	CD4⁺ CD25^-	CD8⁺	CD4⁺ or CD8⁺	CD4⁺ CD25^+/-	CD4⁺ CD25⁺	CD4⁺ or CD8⁺	CD4⁺ (Tr1)
MHC restriction	Yes	No	No	No	No	No	No	No	No
Suppression mediator
Cytokines	No	Yes	No	Yes	Yes	Yes	Yes	No	Yes
T cell-T cell interaction	No	?	Yes	No	Yes	?	Yes	Yes	Yes
T cell-APC interaction	Yes	?	Yes	No	Yes	?	?	Yes	?
Antigen specificity	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes
Reference number	29	31, 32, 34	38	27	52-55	23, 26, 43	58	65-67	68

Ts indicates regulatory T cells induced by stimulating peripheral blood mononuclear cells (PBMCs) with irradiated allogeneic PBMCs depleted of CD2⁺ cells; M-DCs, mature myeloid dendritic cells; PDCs: plasmacytoid dendritic cells; iDCs, immature myeloid dendritic cells; LFA-3, leukocyte function- associated antigen 3; Notch-L, Notch ligand; IL10: interleukin 10; ?, unknown.

CD3, CD4, CD8, CD40 ligand mAbs.

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