Prognostic factors in 23 cases of natural killer cell lymphomas: significance of presentation parameters
. | . | P . | . | . | P . | . | ||
|---|---|---|---|---|---|---|---|---|
| Parameters . | Median DFS, mo . | Univariate . | Multivariate . | Median OS, mo . | Univariate . | Multivariate . | ||
| Histologic subtypes | ||||||||
| Nasal | 21.5 | 30.6 | ||||||
| Nonnasal | 0.3 | 1.5 | ||||||
| Disseminated | 0.0 | .001 | NS (.43) | 0.7 | .009 | NS (.57) | ||
| Age, y | ||||||||
| Younger than 60 | 1.4 | 4.2 | ||||||
| Older than 60 | 1.2 | NS (.9) | — | 4.3 | NS (.8) | — | ||
| Stage | ||||||||
| I/II | 21.5 | 30.6 | ||||||
| III/IV | 0.5 | .004 | NS (.59) | 2.1 | .008 | NS (.56) | ||
| LDH | ||||||||
| Less than 2 times normal | 2.7 | 4.5 | ||||||
| More than 2 times normal | 1.2 | NS (.30) | — | 3.7 | NS (.48) | — | ||
| IPI | ||||||||
| Up to 1 | 2.7 | 30.6 | ||||||
| More than 2 | 0.5 | NS (.059) | — | 2.7 | NS (.075) | — | ||
| EBV DNA at presentation | ||||||||
| Less than 6.1 × 107 copies/mL | >27.0 | > 54.0 | ||||||
| At least 6.1 × 107 copies/mL | 0.5 | .002 | .025 | 2.1 | .008 | .06 | ||
. | . | P . | . | . | P . | . | ||
|---|---|---|---|---|---|---|---|---|
| Parameters . | Median DFS, mo . | Univariate . | Multivariate . | Median OS, mo . | Univariate . | Multivariate . | ||
| Histologic subtypes | ||||||||
| Nasal | 21.5 | 30.6 | ||||||
| Nonnasal | 0.3 | 1.5 | ||||||
| Disseminated | 0.0 | .001 | NS (.43) | 0.7 | .009 | NS (.57) | ||
| Age, y | ||||||||
| Younger than 60 | 1.4 | 4.2 | ||||||
| Older than 60 | 1.2 | NS (.9) | — | 4.3 | NS (.8) | — | ||
| Stage | ||||||||
| I/II | 21.5 | 30.6 | ||||||
| III/IV | 0.5 | .004 | NS (.59) | 2.1 | .008 | NS (.56) | ||
| LDH | ||||||||
| Less than 2 times normal | 2.7 | 4.5 | ||||||
| More than 2 times normal | 1.2 | NS (.30) | — | 3.7 | NS (.48) | — | ||
| IPI | ||||||||
| Up to 1 | 2.7 | 30.6 | ||||||
| More than 2 | 0.5 | NS (.059) | — | 2.7 | NS (.075) | — | ||
| EBV DNA at presentation | ||||||||
| Less than 6.1 × 107 copies/mL | >27.0 | > 54.0 | ||||||
| At least 6.1 × 107 copies/mL | 0.5 | .002 | .025 | 2.1 | .008 | .06 | ||
NS indicates not significant; —, not done.