Table 2. Effect of various ABC... | American Society of Hematology

Table 2.

Effect of various ABC transporter inhibitors on human CD34⁺ cell transduction

	Fold change vs no drug control
	LTC-IC transduction	CD34⁺ transduction	CD34⁺ viability	4-day fold expansion
Untransduced	NA	NA	1.15 ± 0.14	2.8 ± 1.0
No drug	1.0 ± 0.0	1.0 ± 0.0	1.00 ± 0.00	1.6 ± 0.7
Verapamil	3.7 ± 1.9	3.4 ± 1.6	0.52 ± 0.19	1.4 ± 1.1
Diltiazem	2.8 ± 1.2	2.5 ± 0.9	0.76 ± 0.21	1.2 ± 0.8
Quinidine	3.6 ± 1.6	3.0 ± 1.7	0.43 ± 0.23	0.7 ± 0.6
Ritonavir	2.2 ± 1.4	2.0 ± 1.1	0.72 ± 0.32	1.2 ± 1.1
Probenecid	1.5 ± 0.0	1.5 ± 0.2	0.85 ± 0.30	1.5 ± 0.7
Reserpine	0.8 ± 0.3	1.0 ± 0.0	0.54 ± 0.06	1.0 ± 0.2
Sodium vanadate	0.6^*	0.9^*	0.46^*	0.5^*
Arsenic trioxide	2.0^*	2.0^*	0.85^*	1.4^*
α-tocopherol	1.2^*	1.2^*	0.93^*	1.0^*
Quinidine + verapamil	2.9^*	5.1^*	0.39^*	0.6^*
Diltiazem + verapamil	3.7^*	3.6^*	0.43^*	0.9^*
Quinidine + diltiazem	4.5^*	3.1^*	0.43^*	0.5^*
Quinidine + ritonavir	4.4^*	5.1^*	0.34^*	1.0^*
Ritonavir + verapamil	ND	2.9^*	0.56^*	0.7^*
Diltiazem + ritonavir	ND	6.1^*	0.44^*	0.4^*

	Fold change vs no drug control
	LTC-IC transduction	CD34⁺ transduction	CD34⁺ viability	4-day fold expansion
Untransduced	NA	NA	1.15 ± 0.14	2.8 ± 1.0
No drug	1.0 ± 0.0	1.0 ± 0.0	1.00 ± 0.00	1.6 ± 0.7
Verapamil	3.7 ± 1.9	3.4 ± 1.6	0.52 ± 0.19	1.4 ± 1.1
Diltiazem	2.8 ± 1.2	2.5 ± 0.9	0.76 ± 0.21	1.2 ± 0.8
Quinidine	3.6 ± 1.6	3.0 ± 1.7	0.43 ± 0.23	0.7 ± 0.6
Ritonavir	2.2 ± 1.4	2.0 ± 1.1	0.72 ± 0.32	1.2 ± 1.1
Probenecid	1.5 ± 0.0	1.5 ± 0.2	0.85 ± 0.30	1.5 ± 0.7
Reserpine	0.8 ± 0.3	1.0 ± 0.0	0.54 ± 0.06	1.0 ± 0.2
Sodium vanadate	0.6^*	0.9^*	0.46^*	0.5^*
Arsenic trioxide	2.0^*	2.0^*	0.85^*	1.4^*
α-tocopherol	1.2^*	1.2^*	0.93^*	1.0^*
Quinidine + verapamil	2.9^*	5.1^*	0.39^*	0.6^*
Diltiazem + verapamil	3.7^*	3.6^*	0.43^*	0.9^*
Quinidine + diltiazem	4.5^*	3.1^*	0.43^*	0.5^*
Quinidine + ritonavir	4.4^*	5.1^*	0.34^*	1.0^*
Ritonavir + verapamil	ND	2.9^*	0.56^*	0.7^*
Diltiazem + ritonavir	ND	6.1^*	0.44^*	0.4^*

Data are presented as mean ± SD. See also Figure 4. NA indicates not applicable; and ND, not done.

Single experiment.