Table 2.

Genes down-regulated more 2-fold in the CD34+/CD38- fraction versus CD34+/CD38+


Gene

Symbol

Accession no.

Ratio (Log2)

SD
Cell surface receptors/ligands     
    CD38 antigen* CD38  AA417096   -1.9   0.5  
    Kell blood group protein  KEL H61054  -1.1   0.8  
    IL-7 receptor  IL7 N95337  -1.5   0.9  
    CD24 antigen CD24 R96738  -1.8   1.6  
    Antigen of monoclonal antibody ki-67 MKI67 T72662  -1.3   0.6  
    Colony-stimulating factor 2 receptor β* CSF2RB H04648  -1.8   0.3  
    T-cell receptor ti rearranged γ-chain mRNA V-J-C region TRG R77295  -2.1   0.9  
    CD36 antigen CD36 R09416  -1.2   0.4  
    Ig rearranged γ chain mRNA, V-J-C region IGKC R10121  -1.2   0.3  
    High-affinity IgE receptor α subunit (fceri) FCER1A  AI676097   -1.1   0.5  
    Ig-related 14.1 protein IGLL1 W73587  -1.2   0.5  
    Hepatocyte growth factor (HGF) HGF R37604  -1.0   0.6  
    Macrophage inflammatory protein-1α/RANTES receptor CCR1  AI570752   -1.1   0.4  
Transporter/signal transduction     
    Solute carrier family 11 SLC11A3 T97261  -1.2   0.5  
    5-Lipoxygenase activating protein (FLAP) ALOX5AP H02307  -2.1   0.8  
    Ionotropic ATP receptor p2×5a mRNA P2RX5  AF070573   -1.2   0.0  
    Very-long-chain acyl-CoA synthetase* FACVL1  AA417046   -1.2   0.2  
    L-histidine decarboxylase* HDC  AI695885   -3.7   0.7  
    Lymphoid enhancer-binding factor-1 LEF1 W81128  -1.6   0.7  
Transcription factors/cell cycle     
    Cyclin PCNA* PCNA T82974  -1.0   0.1  
    Cyclin B2* CCNB2  AA129846   -1.3   0.3  
    Erythroid Kruppel-like factor (EKLF)* KLF/1 H65733  -1.6   0.3  
    ESTs, weakly similar to nucleolin   AA437223   -1.2   0.7  
    Homo sapiens myostatin (gdf8) GDF8 H92027  -1.1   0.6  
Cellular component/cytoskeleton     
    Pleckstrin (p47) PLEK R05932  -1.0   0.4  
    Mast cell carboxypeptidase a (MC-CPA)* CPA3 N79582  -1.9   0.4  
    Light and heavy chains of myeloperoxidase* MPO R05801  -3.3   0.5  
    Kinesin-like 7* KNSL7  AI623136   -1.5   0.4  
    Kinesin-like 5 (mitotic kinesin-like protein 1)* KNSL5  AI288408   -1.0   0.2  
Other/unknown     
    kiaa0473 protein* DNAJC6 N38951  -1.1   0.2  
    hspc037 protein* LOC51659 H58066  -1.4   0.3  
    kiaa0101 gene* KIAA0101 R36629  -1.6   0.4  
    Retinol dehydrogenase homolog RDHL  AI540484   -1.7   0.5  
    N-acetylglucosamine-6-o-sulfotransferase (glcnac6st) CHST2 N80041  -1.1   0.3  
    Protein associated with glycosphingolipid microdomains PAG N50114  -1.3   0.4  
    Hypothetical protein flj10540* FLJ10540  AI696847   -1.2   0.3  
    zw10 interactor zwin ZWINT  AA292765   -1.2   0.4  
    Factor XIII subunit a FI3A1 H67759  -1.4   0.6  
    Hyaluronan receptor (rhamm)
 
HMMR
 
AA460915
 
-1.5
 
0.8
 

Gene

Symbol

Accession no.

Ratio (Log2)

SD
Cell surface receptors/ligands     
    CD38 antigen* CD38  AA417096   -1.9   0.5  
    Kell blood group protein  KEL H61054  -1.1   0.8  
    IL-7 receptor  IL7 N95337  -1.5   0.9  
    CD24 antigen CD24 R96738  -1.8   1.6  
    Antigen of monoclonal antibody ki-67 MKI67 T72662  -1.3   0.6  
    Colony-stimulating factor 2 receptor β* CSF2RB H04648  -1.8   0.3  
    T-cell receptor ti rearranged γ-chain mRNA V-J-C region TRG R77295  -2.1   0.9  
    CD36 antigen CD36 R09416  -1.2   0.4  
    Ig rearranged γ chain mRNA, V-J-C region IGKC R10121  -1.2   0.3  
    High-affinity IgE receptor α subunit (fceri) FCER1A  AI676097   -1.1   0.5  
    Ig-related 14.1 protein IGLL1 W73587  -1.2   0.5  
    Hepatocyte growth factor (HGF) HGF R37604  -1.0   0.6  
    Macrophage inflammatory protein-1α/RANTES receptor CCR1  AI570752   -1.1   0.4  
Transporter/signal transduction     
    Solute carrier family 11 SLC11A3 T97261  -1.2   0.5  
    5-Lipoxygenase activating protein (FLAP) ALOX5AP H02307  -2.1   0.8  
    Ionotropic ATP receptor p2×5a mRNA P2RX5  AF070573   -1.2   0.0  
    Very-long-chain acyl-CoA synthetase* FACVL1  AA417046   -1.2   0.2  
    L-histidine decarboxylase* HDC  AI695885   -3.7   0.7  
    Lymphoid enhancer-binding factor-1 LEF1 W81128  -1.6   0.7  
Transcription factors/cell cycle     
    Cyclin PCNA* PCNA T82974  -1.0   0.1  
    Cyclin B2* CCNB2  AA129846   -1.3   0.3  
    Erythroid Kruppel-like factor (EKLF)* KLF/1 H65733  -1.6   0.3  
    ESTs, weakly similar to nucleolin   AA437223   -1.2   0.7  
    Homo sapiens myostatin (gdf8) GDF8 H92027  -1.1   0.6  
Cellular component/cytoskeleton     
    Pleckstrin (p47) PLEK R05932  -1.0   0.4  
    Mast cell carboxypeptidase a (MC-CPA)* CPA3 N79582  -1.9   0.4  
    Light and heavy chains of myeloperoxidase* MPO R05801  -3.3   0.5  
    Kinesin-like 7* KNSL7  AI623136   -1.5   0.4  
    Kinesin-like 5 (mitotic kinesin-like protein 1)* KNSL5  AI288408   -1.0   0.2  
Other/unknown     
    kiaa0473 protein* DNAJC6 N38951  -1.1   0.2  
    hspc037 protein* LOC51659 H58066  -1.4   0.3  
    kiaa0101 gene* KIAA0101 R36629  -1.6   0.4  
    Retinol dehydrogenase homolog RDHL  AI540484   -1.7   0.5  
    N-acetylglucosamine-6-o-sulfotransferase (glcnac6st) CHST2 N80041  -1.1   0.3  
    Protein associated with glycosphingolipid microdomains PAG N50114  -1.3   0.4  
    Hypothetical protein flj10540* FLJ10540  AI696847   -1.2   0.3  
    zw10 interactor zwin ZWINT  AA292765   -1.2   0.4  
    Factor XIII subunit a FI3A1 H67759  -1.4   0.6  
    Hyaluronan receptor (rhamm)
 
HMMR
 
AA460915
 
-1.5
 
0.8
 

The Log2 ratios of (CD34+/CD38-) to (CD34+/CD38+) were the average values of 4 hybridizations in 2 experiments. Error estimate is given as SD. Probability of differential gene expression in relation to all high-quality signals was determined with the Student ttest.

ATP indicates adenosine triphosphate; acyl-CoA, acyl-coenzyme A.

*

P < .005.

P < .05.

P < .0005.

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