Table 1. Translocation and cyclin D (TC)... | American Society of Hematology

Table 1.

Translocation and cyclin D (TC) molecular classification of multiple myeloma

Group	Primary translocation	Gene(s) at breakpoint	D-Cyclin	Ploidy	Frequency of each TC group in newly diagnosed MM, %
TC1
	11q13	CCND1	D1	NH	15
	6p21	CCND3	D3	NH	3
TC2	None	None	D2	H	37
TC3	None	None	D2	H = NH	22
TC4	4p16	FGFR3/MMSET	D2	NH > H	16
TC5
	16q23	c-maf	D2	NH	5
	20q11	mafB	D2	NH	2

Group	Primary translocation	Gene(s) at breakpoint	D-Cyclin	Ploidy	Frequency of each TC group in newly diagnosed MM, %
TC1
	11q13	CCND1	D1	NH	15
	6p21	CCND3	D3	NH	3
TC2	None	None	D2	H	37
TC3	None	None	D2	H = NH	22
TC4	4p16	FGFR3/MMSET	D2	NH > H	16
TC5
	16q23	c-maf	D2	NH	5
	20q11	mafB	D2	NH	2

Bergsagel and Kuehl²⁷; and P.L.B., W.M.K., and J. Shaughnessy, unpublished data, January 2004.

H indicates hyperdiploid; NH, nonhyperdiploid.