Factors associated with progression-free survival
Patient and treatment-related variables . | No. of patients (no. of events) . | Median survival, wk . | Univariate P . | HR . | 95% CI for HR . | Multivariate P . | HR . | 95% CI for HR . |
|---|---|---|---|---|---|---|---|---|
| Recipient-donor CMV | ||||||||
| Negative-negative | 12 (8) | 52 | — | 1.00 | — | |||
| Other | 82 (64) | 19 | .30 | 1.47 | 0.70-3.07 | |||
| Recipient age, y | .73 | 1.00 | 0.98-1.03 | |||||
| 57 or younger | 47 (35) | 29 | — | 1.00 | — | — | 1.00 | — |
| Older than 57 | 47 (37) | 16 | .45 | 1.20 | 0.75-1.90 | .21 | 0.70 | 0.41-1.21 |
| Donor-recipient sex | ||||||||
| Female-female | 26 (22) | 27 | — | 1.00 | — | |||
| Female-male | 20 (17) | 14 | .63 | 1.17 | 0.62-2.21 | |||
| Male-female | 23 (16) | 13 | .53 | 0.81 | 0.42-1.56 | |||
| Male-male | 25 (17) | 22 | .46 | 0.78 | 0.41-1.49 | |||
| Duration of first CR | ||||||||
| Less than 6 mo | 70 (54) | 19 | — | 1.00 | — | |||
| 6-12 mo | 14 (12) | 12 | .27 | 1.43 | 0.76-2.68 | |||
| More than 12 mo | 10 (6) | 115 | .13 | 0.52 | 0.22-1.22 | |||
| Cytogenetics | ||||||||
| Bad | 53 (45) | 13 | — | 1.00 | — | 1.00 | — | |
| Intermediate | 38 (24) | 56 | <.01 | 0.47 | 0.29-0.78 | .01 | 0.52 | 0.31-0.87 |
| Missing | 3 (2) | 13 | — | — | ||||
| Disease status | ||||||||
| First CR | 11 (9) | 59 | — | 1.00 | — | — | 1.00 | — |
| More than 1 CR | 13 (5) | — | .07 | 0.36 | 0.12-1.07 | .19 | 0.48 | 0.16-1.45 |
| Refractory | 57 (47) | 14 | .34 | 1.42 | 0.69-2.90 | .09 | 2.00 | 0.89-4.49 |
| Untreated | 13 (11) | 13 | .25 | 1.68 | 0.69-4.07 | .03 | 3.22 | 1.10-9.44 |
| Preparative regimen | ||||||||
| FAI | 32 (27) | 16 | — | 1.00 | — | — | 1.00 | — |
| FM | 62 (45) | 21 | .32 | 0.79 | 0.49-1.27 | .01 | 0.42 | 0.21-0.83 |
| Cell type | ||||||||
| Bone marrow | 41 (31) | 21 | — | 1.00 | — | |||
| Peripheral blood | 53 (41) | 19 | .54 | 1.16 | 0.73-1.85 | |||
| Time from diagnosis to transplantation | 94 | NA | .18 | 1.00 | 0.99-1.00 | |||
| ABO mismatch | ||||||||
| No | 56 (42) | 19 | — | 1.00 | — | |||
| Yes | 37 (29) | 21 | .67 | 1.11 | 0.69-1.78 | |||
| Matched sibling | ||||||||
| No | 43 (32) | 19 | — | 1.00 | — | — | 1.00 | — |
| Yes | 51 (40) | 20 | .67 | 1.11 | 0.69-1.76 | .55 | 0.84 | 0.48-1.49 |
Patient and treatment-related variables . | No. of patients (no. of events) . | Median survival, wk . | Univariate P . | HR . | 95% CI for HR . | Multivariate P . | HR . | 95% CI for HR . |
|---|---|---|---|---|---|---|---|---|
| Recipient-donor CMV | ||||||||
| Negative-negative | 12 (8) | 52 | — | 1.00 | — | |||
| Other | 82 (64) | 19 | .30 | 1.47 | 0.70-3.07 | |||
| Recipient age, y | .73 | 1.00 | 0.98-1.03 | |||||
| 57 or younger | 47 (35) | 29 | — | 1.00 | — | — | 1.00 | — |
| Older than 57 | 47 (37) | 16 | .45 | 1.20 | 0.75-1.90 | .21 | 0.70 | 0.41-1.21 |
| Donor-recipient sex | ||||||||
| Female-female | 26 (22) | 27 | — | 1.00 | — | |||
| Female-male | 20 (17) | 14 | .63 | 1.17 | 0.62-2.21 | |||
| Male-female | 23 (16) | 13 | .53 | 0.81 | 0.42-1.56 | |||
| Male-male | 25 (17) | 22 | .46 | 0.78 | 0.41-1.49 | |||
| Duration of first CR | ||||||||
| Less than 6 mo | 70 (54) | 19 | — | 1.00 | — | |||
| 6-12 mo | 14 (12) | 12 | .27 | 1.43 | 0.76-2.68 | |||
| More than 12 mo | 10 (6) | 115 | .13 | 0.52 | 0.22-1.22 | |||
| Cytogenetics | ||||||||
| Bad | 53 (45) | 13 | — | 1.00 | — | 1.00 | — | |
| Intermediate | 38 (24) | 56 | <.01 | 0.47 | 0.29-0.78 | .01 | 0.52 | 0.31-0.87 |
| Missing | 3 (2) | 13 | — | — | ||||
| Disease status | ||||||||
| First CR | 11 (9) | 59 | — | 1.00 | — | — | 1.00 | — |
| More than 1 CR | 13 (5) | — | .07 | 0.36 | 0.12-1.07 | .19 | 0.48 | 0.16-1.45 |
| Refractory | 57 (47) | 14 | .34 | 1.42 | 0.69-2.90 | .09 | 2.00 | 0.89-4.49 |
| Untreated | 13 (11) | 13 | .25 | 1.68 | 0.69-4.07 | .03 | 3.22 | 1.10-9.44 |
| Preparative regimen | ||||||||
| FAI | 32 (27) | 16 | — | 1.00 | — | — | 1.00 | — |
| FM | 62 (45) | 21 | .32 | 0.79 | 0.49-1.27 | .01 | 0.42 | 0.21-0.83 |
| Cell type | ||||||||
| Bone marrow | 41 (31) | 21 | — | 1.00 | — | |||
| Peripheral blood | 53 (41) | 19 | .54 | 1.16 | 0.73-1.85 | |||
| Time from diagnosis to transplantation | 94 | NA | .18 | 1.00 | 0.99-1.00 | |||
| ABO mismatch | ||||||||
| No | 56 (42) | 19 | — | 1.00 | — | |||
| Yes | 37 (29) | 21 | .67 | 1.11 | 0.69-1.78 | |||
| Matched sibling | ||||||||
| No | 43 (32) | 19 | — | 1.00 | — | — | 1.00 | — |
| Yes | 51 (40) | 20 | .67 | 1.11 | 0.69-1.76 | .55 | 0.84 | 0.48-1.49 |
— indicates reference value; NA, not applicable.