Multivariate analysis of prognostic factors adjusted for randomization strata
. | No complete remission*† . | . | . | Progressive disease* . | . | . | EFS event‡§ . | . | . | Death‡ . | . | . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Factors . | OR . | 95% CI . | P . | OR . | 95% CI . | P . | RR . | 95% CI . | P . | RR . | 95% CI . | P . | ||||||||
| Addition of etoposide | 0.54 | 0.36;0.82 | .003 | 0.63 | 0.34;1.16 | .135 | 0.70 | 0.54;0.89 | .004 | 0.83 | 0.59;1.16 | .276 | ||||||||
| Interval reduction | 0.86 | 0.57;1.28 | .453 | 0.50 | 0.27;0.94 | .032 | 0.93 | 0.73;1.20 | .588 | 0.70 | 0.50;0.99 | .044 | ||||||||
| Stage III/IV | 1.40 | 0.92;2.13 | .116 | 1.64 | 0.89;3.02 | .114 | 1.64 | 1.27;2.10 | < .001 | 1.66 | 1.18;2.35 | .004 | ||||||||
| Bulky disease | 0.95 | 0.60;1.48 | .810 | 2.15 | 1.17;3.96 | .014 | 1.13 | 0.86;1.47 | .373 | 1.63 | 1.15;2.31 | .006 | ||||||||
. | No complete remission*† . | . | . | Progressive disease* . | . | . | EFS event‡§ . | . | . | Death‡ . | . | . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Factors . | OR . | 95% CI . | P . | OR . | 95% CI . | P . | RR . | 95% CI . | P . | RR . | 95% CI . | P . | ||||||||
| Addition of etoposide | 0.54 | 0.36;0.82 | .003 | 0.63 | 0.34;1.16 | .135 | 0.70 | 0.54;0.89 | .004 | 0.83 | 0.59;1.16 | .276 | ||||||||
| Interval reduction | 0.86 | 0.57;1.28 | .453 | 0.50 | 0.27;0.94 | .032 | 0.93 | 0.73;1.20 | .588 | 0.70 | 0.50;0.99 | .044 | ||||||||
| Stage III/IV | 1.40 | 0.92;2.13 | .116 | 1.64 | 0.89;3.02 | .114 | 1.64 | 1.27;2.10 | < .001 | 1.66 | 1.18;2.35 | .004 | ||||||||
| Bulky disease | 0.95 | 0.60;1.48 | .810 | 2.15 | 1.17;3.96 | .014 | 1.13 | 0.86;1.47 | .373 | 1.63 | 1.15;2.31 | .006 | ||||||||
OR indicates odds ratio; and RR, relative risk.
Logistic regression (OR).
No complete remission: partial response, stable disease, progressive disease, therapy-associated deaths, unknown response, additional therapy.
Cox proportional models (RR).
EFS events: progression, no complete remission at the end of treatment, relapse after complete remission, death, unplanned additional treatment or change of treatment, whatever comes first.