WHO grade 3 and grade 4 events observed in patients treated with CHOP-21, CHOP-14, CHOEP-21, and CHOEP-14
. | CHOP-21, % . | CHOP-14, % . | CHOEP-21, % . | CHOEP-14, % . | P . |
|---|---|---|---|---|---|
| Leukocytopenia | 72.1 | 70.1 | 94.4 | 92.4 | < .001 |
| Thrombocytopenia | 4.7 | 15.1 | 28.4 | 50.8 | < .001 |
| Anemia | 12.5 | 19.5 | 28.7 | 45.1 | < .001 |
| Infection | 8.0 | 10.6 | 13.2 | 24.1 | < .001 |
| Mucositis | 0.0 | 7.1 | 4.9 | 14.3 | < .001 |
| Cardiac toxicity | 3.4 | 4.7 | 3.7 | 5.0 | .871 |
| Neurologic toxicity | 3.4 | 3.6 | 6.1 | 4.3 | .617 |
| Renal toxicity | 1.1 | 0.0 | 0.6 | 0.6 | .756 |
| Lung toxicity | 4.0 | 4.7 | 3.0 | 6.2 | .560 |
| Nausea or vomiting | 8.0 | 13.5 | 9.7 | 15.4 | .126 |
| Alopecia | 62.5 | 58.3 | 58.2 | 52.7 | .328 |
. | CHOP-21, % . | CHOP-14, % . | CHOEP-21, % . | CHOEP-14, % . | P . |
|---|---|---|---|---|---|
| Leukocytopenia | 72.1 | 70.1 | 94.4 | 92.4 | < .001 |
| Thrombocytopenia | 4.7 | 15.1 | 28.4 | 50.8 | < .001 |
| Anemia | 12.5 | 19.5 | 28.7 | 45.1 | < .001 |
| Infection | 8.0 | 10.6 | 13.2 | 24.1 | < .001 |
| Mucositis | 0.0 | 7.1 | 4.9 | 14.3 | < .001 |
| Cardiac toxicity | 3.4 | 4.7 | 3.7 | 5.0 | .871 |
| Neurologic toxicity | 3.4 | 3.6 | 6.1 | 4.3 | .617 |
| Renal toxicity | 1.1 | 0.0 | 0.6 | 0.6 | .756 |
| Lung toxicity | 4.0 | 4.7 | 3.0 | 6.2 | .560 |
| Nausea or vomiting | 8.0 | 13.5 | 9.7 | 15.4 | .126 |
| Alopecia | 62.5 | 58.3 | 58.2 | 52.7 | .328 |
Values presented represent the percentage of patients who experienced the respective grade 3 and 4 event.