Table 1. Alemtuzumab dose and serum... | American Society of Hematology

Table 1.

Alemtuzumab dose and serum concentrations: intravenous study

Patient no.	Cumulative dose, mg	Number of samples	Terminal samples	Dose to reach 1 μg/mL	Maximum peak, μg/mL	Maximum trough, μg/mL	Before last dose, μg/mL	After last dose, μg/mL
001	1026	80	12	143	16.3	8.3	7.7	11.7
002	673	56	12	13	19.1	13.0	13.0	19.1
003	1106	91	23	43	6.7	1.1	0.9	5.9
004	836	54	0	103	26.4	18.3	ND	ND
005	1064	69	7	46	16.3	6.2	6.2	16.3
006	736	55	8	16	9.5	3.7	2.6	8.5
007	1093	75	11	133	19.8	11.9	11.9	16.4
008	291	19	3	111	5.8	0.7	0.7	0.7
009	1026	73	12	53	13.1	7.7	7.7	12.2
010	179	21	0	46	4.0	0.8	ND	ND
011	1076	71	11	133	8.3	1.9	1.9	8.3
012	473	28	0	53	4.4	0.2	ND	ND
013	946	60	13	183	4.0	0.5	< 0.5	2.9
014	436	31	0	46	12.5	9.9	ND	ND
015	2053	89	0	43	6.4	2.8	ND	ND
016	1016	58	11	103	9.5	4.9	4.5	9.0
017	1093	55	8	133	6.6	1.7	1.2	6.0
018	733	40	1	43	8.2	2.6	ND	ND
019	493	27	1	73	19.9	14.8	ND	ND
020	1093	55	12	43	17.7	9.4	7.7	12.9
021	583	32	0	163	4.0	1.1	ND	ND
022	1003	45	9	43	7.1	1.0	0.6	6.3
023	1063	47	6	43	26.0	17.0	ND	24.1
024	1126	57	12	316	6.0	2.6	2.0	5.5
025	1093	54	11	73	6.9	5.2	3.1	6.7
026	969	57	13	133	5.4	1.5	1.4	4.7
027	1066	45	10	73	2.8	0.9	< 0.5	2.5
028	673	42	13	43	8.5	4.0	4.0	6.9
029	416	40	10	133	7.6	3.3	3.3	7.6
030	763	35	5	133	12.2	3.7	3.7	12.2
Minimum	179	19	0	13	2.8	< 0.5	< 0.5	0.7
Mean	873	52	8	90.4	10.7	5.4	4.0	9.4
Maximum	2063	91	23	316	26.4	18.3	13.0	24.1

Patient no.	Cumulative dose, mg	Number of samples	Terminal samples	Dose to reach 1 μg/mL	Maximum peak, μg/mL	Maximum trough, μg/mL	Before last dose, μg/mL	After last dose, μg/mL
001	1026	80	12	143	16.3	8.3	7.7	11.7
002	673	56	12	13	19.1	13.0	13.0	19.1
003	1106	91	23	43	6.7	1.1	0.9	5.9
004	836	54	0	103	26.4	18.3	ND	ND
005	1064	69	7	46	16.3	6.2	6.2	16.3
006	736	55	8	16	9.5	3.7	2.6	8.5
007	1093	75	11	133	19.8	11.9	11.9	16.4
008	291	19	3	111	5.8	0.7	0.7	0.7
009	1026	73	12	53	13.1	7.7	7.7	12.2
010	179	21	0	46	4.0	0.8	ND	ND
011	1076	71	11	133	8.3	1.9	1.9	8.3
012	473	28	0	53	4.4	0.2	ND	ND
013	946	60	13	183	4.0	0.5	< 0.5	2.9
014	436	31	0	46	12.5	9.9	ND	ND
015	2053	89	0	43	6.4	2.8	ND	ND
016	1016	58	11	103	9.5	4.9	4.5	9.0
017	1093	55	8	133	6.6	1.7	1.2	6.0
018	733	40	1	43	8.2	2.6	ND	ND
019	493	27	1	73	19.9	14.8	ND	ND
020	1093	55	12	43	17.7	9.4	7.7	12.9
021	583	32	0	163	4.0	1.1	ND	ND
022	1003	45	9	43	7.1	1.0	0.6	6.3
023	1063	47	6	43	26.0	17.0	ND	24.1
024	1126	57	12	316	6.0	2.6	2.0	5.5
025	1093	54	11	73	6.9	5.2	3.1	6.7
026	969	57	13	133	5.4	1.5	1.4	4.7
027	1066	45	10	73	2.8	0.9	< 0.5	2.5
028	673	42	13	43	8.5	4.0	4.0	6.9
029	416	40	10	133	7.6	3.3	3.3	7.6
030	763	35	5	133	12.2	3.7	3.7	12.2
Minimum	179	19	0	13	2.8	< 0.5	< 0.5	0.7
Mean	873	52	8	90.4	10.7	5.4	4.0	9.4
Maximum	2063	91	23	316	26.4	18.3	13.0	24.1

ND indicates not determined.