GVHD response to denileukin diftitox by dose level, organ involvement, and severity.
. | CR, no. (%) . | PR, no. (%) . | OR, no. (%) . |
|---|---|---|---|
| Drug dose | |||
| Level 1 | 1/7 (14) | 4/7 (57) | 5/7 (71) |
| Level 2 | 6/13 (46) | 3/13 (23) | 9/13 (69) |
| Level 3* | 1/4 (25) | 2/4 (50) | 3/4 (75) |
| Overall | 8/24 (33) | 9/24 (38)† | 17/24 (71) |
| Organs involved | |||
| Skin | 7/16 (44) | 4/16 (25) | 11/16 (69) |
| Intestine | 9/16 (56) | 3/16 (19) | 12/16 (75) |
| Liver | 1/4 (25) | 0 | 1/4 (25) |
| GVHD grade at enrollment | |||
| II | 1/8 (13) | 4/8 (50) | 5/8 (63) |
| III | 5/13 (38) | 4/13 (31) | 9/13 (69) |
| IV | 2/3 (67) | 1/3 (33) | 3/3 (100) |
. | CR, no. (%) . | PR, no. (%) . | OR, no. (%) . |
|---|---|---|---|
| Drug dose | |||
| Level 1 | 1/7 (14) | 4/7 (57) | 5/7 (71) |
| Level 2 | 6/13 (46) | 3/13 (23) | 9/13 (69) |
| Level 3* | 1/4 (25) | 2/4 (50) | 3/4 (75) |
| Overall | 8/24 (33) | 9/24 (38)† | 17/24 (71) |
| Organs involved | |||
| Skin | 7/16 (44) | 4/16 (25) | 11/16 (69) |
| Intestine | 9/16 (56) | 3/16 (19) | 12/16 (75) |
| Liver | 1/4 (25) | 0 | 1/4 (25) |
| GVHD grade at enrollment | |||
| II | 1/8 (13) | 4/8 (50) | 5/8 (63) |
| III | 5/13 (38) | 4/13 (31) | 9/13 (69) |
| IV | 2/3 (67) | 1/3 (33) | 3/3 (100) |