Clinical information of patients with apoptosis-proficient and apoptosis-resistant ALL tumors
ALL . | Age at diagnosis, y . | WBC count at diagnosis, × 109/L . | Length of first CR, mo . | Clinical outcome . | Prognostic cytogenetic abnormality . |
|---|---|---|---|---|---|
| Apoptosis-proficient | |||||
| 32 | 12 | 210 | 56 | CR | — |
| 33 | 7 | 195 | 10 | R | — |
| 69 | 4 | 19 | 11 | CR | Hyperdiploid (55) |
| 70 | 6 | 56 | 11 | Regimen change | — |
| 74 | 2 | 7 | 62 | CR | Hyperdiploid (55) |
| 12 | 4 | 96 | 19 | R | — |
| 2 | 7 | 49 | 41 | CR | t(12;21) |
| 72 | 3 | 16 | 8 | CR | Hyperdiploid (58-59) |
| 90 | 2 | 11 | 0 | CR | Hyperdiploid (56) |
| 91 | 7 | 7 | 4 | CR | Hyperdiploid (57) |
| 92 | 6 | 47 | 0 | CR | t(12;21) |
| 86 | 11 | 4 | 1 | D | Hyperdiploid (55) |
| 88 | 5 | 6 | 1 | CR | — |
| 76 | 5 | 8 | 36 | CR | TEL-AML ×2 |
| 17 | 3 | 12 | 34 | CR | t(12;21) |
| 75 | 9 | 330 | 7 | CR | — |
| 71 | 2 | 37 | 24 | CR | Hyperdiploid (54-56) |
| 34r | 3 | 41 | 65 | R | Hyperdiploid (58) |
| 42r | 3 | 68 | 33 | R | — |
| 89r | 15 | 3 | 35 | R | Hyperdiploid (53) |
| 21r | 15 | 55 | 9 | R | — |
| Apoptosis-resistant (normal p53 response) | |||||
| 20 | 18 | 118 | 42 | CR (BMT as standard) | — |
| 24 | 4 | 15 | 28 | Regimen change | TEL-AML 1(complex translocation) |
| 53 | 12 | 106 | 11 | R | — |
| 9 | 10 | 6 | 56 | CR | t(12;21) |
| 27 | 15 | 13 | 59 | CR | t(1;19) |
| 78 | 15 | 18 | 9 | CR | t(12;21) |
| 79 | 4 | 8 | 25 | R | — |
| 82 | 3 | 6 | 5 | CR | Hyperdiploid (50) |
| 84 | 7 | 21 | 7 | CR | — |
| 85 | 14 | 202 | 4 | CR | — |
| 93 | 5 | 3 | 1 | CR | — |
| 80r | 3 | 35 | 41 | R | t(12;21) |
| 81r | 4 | 18 | 72 | R | Hyperdiploid (56) |
| 36r | 8 | 20 | 43 | R | t(1;19) |
| 83r | 4 | 237 | 19 | R | Hyperdiploid (53) |
| Apoptosis-resistant (defective p53 response) | |||||
| 19* | 13 | 69 | 16 | R and D | — |
| 22† | 2 | 140 | 31 | Regimen change | t(1;19) |
| 77r† | 9 | 2 | 38 | R | t(12;21) |
| 87r† | 11 | 16 | 11 | R | Near haploid (27) |
ALL . | Age at diagnosis, y . | WBC count at diagnosis, × 109/L . | Length of first CR, mo . | Clinical outcome . | Prognostic cytogenetic abnormality . |
|---|---|---|---|---|---|
| Apoptosis-proficient | |||||
| 32 | 12 | 210 | 56 | CR | — |
| 33 | 7 | 195 | 10 | R | — |
| 69 | 4 | 19 | 11 | CR | Hyperdiploid (55) |
| 70 | 6 | 56 | 11 | Regimen change | — |
| 74 | 2 | 7 | 62 | CR | Hyperdiploid (55) |
| 12 | 4 | 96 | 19 | R | — |
| 2 | 7 | 49 | 41 | CR | t(12;21) |
| 72 | 3 | 16 | 8 | CR | Hyperdiploid (58-59) |
| 90 | 2 | 11 | 0 | CR | Hyperdiploid (56) |
| 91 | 7 | 7 | 4 | CR | Hyperdiploid (57) |
| 92 | 6 | 47 | 0 | CR | t(12;21) |
| 86 | 11 | 4 | 1 | D | Hyperdiploid (55) |
| 88 | 5 | 6 | 1 | CR | — |
| 76 | 5 | 8 | 36 | CR | TEL-AML ×2 |
| 17 | 3 | 12 | 34 | CR | t(12;21) |
| 75 | 9 | 330 | 7 | CR | — |
| 71 | 2 | 37 | 24 | CR | Hyperdiploid (54-56) |
| 34r | 3 | 41 | 65 | R | Hyperdiploid (58) |
| 42r | 3 | 68 | 33 | R | — |
| 89r | 15 | 3 | 35 | R | Hyperdiploid (53) |
| 21r | 15 | 55 | 9 | R | — |
| Apoptosis-resistant (normal p53 response) | |||||
| 20 | 18 | 118 | 42 | CR (BMT as standard) | — |
| 24 | 4 | 15 | 28 | Regimen change | TEL-AML 1(complex translocation) |
| 53 | 12 | 106 | 11 | R | — |
| 9 | 10 | 6 | 56 | CR | t(12;21) |
| 27 | 15 | 13 | 59 | CR | t(1;19) |
| 78 | 15 | 18 | 9 | CR | t(12;21) |
| 79 | 4 | 8 | 25 | R | — |
| 82 | 3 | 6 | 5 | CR | Hyperdiploid (50) |
| 84 | 7 | 21 | 7 | CR | — |
| 85 | 14 | 202 | 4 | CR | — |
| 93 | 5 | 3 | 1 | CR | — |
| 80r | 3 | 35 | 41 | R | t(12;21) |
| 81r | 4 | 18 | 72 | R | Hyperdiploid (56) |
| 36r | 8 | 20 | 43 | R | t(1;19) |
| 83r | 4 | 237 | 19 | R | Hyperdiploid (53) |
| Apoptosis-resistant (defective p53 response) | |||||
| 19* | 13 | 69 | 16 | R and D | — |
| 22† | 2 | 140 | 31 | Regimen change | t(1;19) |
| 77r† | 9 | 2 | 38 | R | t(12;21) |
| 87r† | 11 | 16 | 11 | R | Near haploid (27) |
Shown for each patient are age and WBC at diagnosis, length of first continuous remission (CR), clinical outcome (R, relapse; D, death), and prognostic cytogenetic abnormalities (—, absence of prognostic cytogenetic abnormality; number of chromosomes is given in parentheses alongside ploidy status).
TP53 mutant.
Defective activation of p53 (possible ATM inactivation).