Pre-BMT characteristics of patients and their influence on the incidence of HVOD
. | . | . | Univariate analysis . | . | . | Multivariate analysis . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
. | With HVOD . | No HVOD . | OR . | 95% CI . | P . | OR . | 95% CI . | P . | ||||
| Age, y, mean ± SD | 9.58 ± 4.6 | 6.52 ± 3.8 | 0.844 | 0.76-0.94 | .0014 | 0.832 | 0.71-0.98 | .02 | ||||
| Serum bilirubin level, μM, mean ± SD | 20.18 ± 11.97 | 15.05 ± 7.7 | 0.38 | 0.179-0.803 | .0112 | 0.488 | 0.201-1.18 | .112 | ||||
| Serum ferrilin, ng/mL, mean ± SD | 3799 ± 1728 | 3400 ± 2095 | 0.999 | 0.99-1.0 | .334 | 1.002 | 0.99-1.0 | 0.528 | ||||
| AST, U/L, mean ± SD | 98 ± 74 | 61 ± 28 | 0.984 | 0.97-0.99 | .0014 | 0.988 | 0.97-1.0 | .143 | ||||
| ALT, U/L, mean ± SD | 132 ± 102 | 77 ± 56 | 0.99 | 0.98-0.99 | .0016 | 0.997 | 0.988-1.0 | .52 | ||||
| Lucarelli, n | ||||||||||||
| Class I | 2 | 7 | 1.0 | NA | NA | 1.0 | NA | NA | ||||
| Class II | 10 | 39 | 2.1 | 0.39-11 | .38 | 2.246 | 0.28-17.6 | .441 | ||||
| Class III | 21 | 35 | 2.34 | 0.97-5.6 | .058 | 2.062 | 0.22-19.54 | .528 | ||||
| Hepatitis B/C infection, n | 8 | 4 | 6.16 | 1.7-22.2 | .0055 | 1.583 | 0.23-10.7 | .34 | ||||
| GSTM1-null genotype, n | 20 | 23 | 4.12 | 1.76-9.67 | .0011 | 4.29 | 1.46-12.53 | .0078 | ||||
| GSTT1-null genotype, n | 6 | 28 | 0.421 | 0.155-1.14 | .0884 | 0.563 | 0.163-1.94 | .362 | ||||
. | . | . | Univariate analysis . | . | . | Multivariate analysis . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
. | With HVOD . | No HVOD . | OR . | 95% CI . | P . | OR . | 95% CI . | P . | ||||
| Age, y, mean ± SD | 9.58 ± 4.6 | 6.52 ± 3.8 | 0.844 | 0.76-0.94 | .0014 | 0.832 | 0.71-0.98 | .02 | ||||
| Serum bilirubin level, μM, mean ± SD | 20.18 ± 11.97 | 15.05 ± 7.7 | 0.38 | 0.179-0.803 | .0112 | 0.488 | 0.201-1.18 | .112 | ||||
| Serum ferrilin, ng/mL, mean ± SD | 3799 ± 1728 | 3400 ± 2095 | 0.999 | 0.99-1.0 | .334 | 1.002 | 0.99-1.0 | 0.528 | ||||
| AST, U/L, mean ± SD | 98 ± 74 | 61 ± 28 | 0.984 | 0.97-0.99 | .0014 | 0.988 | 0.97-1.0 | .143 | ||||
| ALT, U/L, mean ± SD | 132 ± 102 | 77 ± 56 | 0.99 | 0.98-0.99 | .0016 | 0.997 | 0.988-1.0 | .52 | ||||
| Lucarelli, n | ||||||||||||
| Class I | 2 | 7 | 1.0 | NA | NA | 1.0 | NA | NA | ||||
| Class II | 10 | 39 | 2.1 | 0.39-11 | .38 | 2.246 | 0.28-17.6 | .441 | ||||
| Class III | 21 | 35 | 2.34 | 0.97-5.6 | .058 | 2.062 | 0.22-19.54 | .528 | ||||
| Hepatitis B/C infection, n | 8 | 4 | 6.16 | 1.7-22.2 | .0055 | 1.583 | 0.23-10.7 | .34 | ||||
| GSTM1-null genotype, n | 20 | 23 | 4.12 | 1.76-9.67 | .0011 | 4.29 | 1.46-12.53 | .0078 | ||||
| GSTT1-null genotype, n | 6 | 28 | 0.421 | 0.155-1.14 | .0884 | 0.563 | 0.163-1.94 | .362 | ||||
The conversion factor for serum bilirubin level is as follows: mg/dL × 17.1 = μM.
NA indicates not applicable.