Table 5. Mutation of AML1 related to the... | American Society of Hematology

Table 5.

Mutation of AML1 related to the FAB subtypes of the 33 patients transforming from t-MDS to t-AML

	AML1 mutated N = 15	AML1 wild-type N = 18	P
FAB subtypes before transformation
RA + RARS	3	14	.008*
RAEB + RAEB-t	9	4
Unclassifiable	3	0	NS
Duration of t-MDS, median, in months	4.5	11	.08†
FAB subtypes after transformation
M0	0	1	NS
M1	3	4	NS
M2	3	2	NS
M4	7	7	NS
M6	0	1	NS
Unclassifiable	2	3	NS

	AML1 mutated N = 15	AML1 wild-type N = 18	P
FAB subtypes before transformation
RA + RARS	3	14	.008*
RAEB + RAEB-t	9	4
Unclassifiable	3	0	NS
Duration of t-MDS, median, in months	4.5	11	.08†
FAB subtypes after transformation
M0	0	1	NS
M1	3	4	NS
M2	3	2	NS
M4	7	7	NS
M6	0	1	NS
Unclassifiable	2	3	NS

NS indicates not significant.

Fisher exact test (2-sided) was used to determine P value. Value was calculated among RA + RARS and RAEB + RAEB-t subsets.

Wilcoxon 2-sample test.