Toxicity with hyper-CVAD or modified hyper-CVAD for LL (n = 33)
. | . | Percent of patients . | . | |
|---|---|---|---|---|
| Parameter . | No. . | Grades 1-2 . | Grades 3-4 . | |
| Infections during induction (71 courses)* | ||||
| FUO | 13 | — | 13 | |
| Sepsis | 8 | — | 8 | |
| Pneumonia | 2 | — | 2 | |
| Fungal | 1 | — | 1 | |
| Infections during consolidation (131 courses) | ||||
| FUO | 32 | — | 32 | |
| Sepsis | 9 | — | 9 | |
| Pneumonia | 8 | — | 8 | |
| Fungal | 2 | — | 2 | |
| Other | 5 | — | 5 | |
| Gastrointestinal | ||||
| Stomatitis | 15 | 33 | 12 | |
| Nausea/vomiting | 6 | 15 | 3 | |
| Ileus | 1 | 0 | 3 | |
| Renal | ||||
| Increase in creatinine | 1 | 3 | 0 | |
| Neuromuscular | ||||
| Peripheral neuropathy | 5 | 9 | 3 | |
| Cardiovascular | ||||
| Pericarditis | 1 | 0 | 3 | |
| Hepatic | ||||
| Increase in bilirubin | 3 | 6 | 3 | |
| Increase in transaminases | 6 | 6 | 12 | |
| Pancreatitis | 1 | 0 | 3 | |
| Dermatologic | ||||
| Rash | 1 | 0 | 3 | |
. | . | Percent of patients . | . | |
|---|---|---|---|---|
| Parameter . | No. . | Grades 1-2 . | Grades 3-4 . | |
| Infections during induction (71 courses)* | ||||
| FUO | 13 | — | 13 | |
| Sepsis | 8 | — | 8 | |
| Pneumonia | 2 | — | 2 | |
| Fungal | 1 | — | 1 | |
| Infections during consolidation (131 courses) | ||||
| FUO | 32 | — | 32 | |
| Sepsis | 9 | — | 9 | |
| Pneumonia | 8 | — | 8 | |
| Fungal | 2 | — | 2 | |
| Other | 5 | — | 5 | |
| Gastrointestinal | ||||
| Stomatitis | 15 | 33 | 12 | |
| Nausea/vomiting | 6 | 15 | 3 | |
| Ileus | 1 | 0 | 3 | |
| Renal | ||||
| Increase in creatinine | 1 | 3 | 0 | |
| Neuromuscular | ||||
| Peripheral neuropathy | 5 | 9 | 3 | |
| Cardiovascular | ||||
| Pericarditis | 1 | 0 | 3 | |
| Hepatic | ||||
| Increase in bilirubin | 3 | 6 | 3 | |
| Increase in transaminases | 6 | 6 | 12 | |
| Pancreatitis | 1 | 0 | 3 | |
| Dermatologic | ||||
| Rash | 1 | 0 | 3 | |