Impact of mismatching on transplant outcome: impact of DRB1 versus class I mismatching in HLA-A, B, DR serologically matched pairs
. | No. . | Grades III—IV acute GVHD, % . | 5-y survival, % . |
|---|---|---|---|
| No high-resolution mismatches | 791 | 30 ± 3 | 39 ± 3 |
| Single mismatch at class I | 317 | 40 ± 5 | 31 ± 5 |
| Single high-resolution mismatch at DRB | 77 | 38 ± 10 | 27 ± 10 |
. | No. . | Grades III—IV acute GVHD, % . | 5-y survival, % . |
|---|---|---|---|
| No high-resolution mismatches | 791 | 30 ± 3 | 39 ± 3 |
| Single mismatch at class I | 317 | 40 ± 5 | 31 ± 5 |
| Single high-resolution mismatch at DRB | 77 | 38 ± 10 | 27 ± 10 |
Shown are comparisons between mismatch at class I versus HLA-DRB1 on acute GVHD (P = .65) and 5-year survival (P = .37). Single mismatches at class I include high-resolution mismatches for HLA-A and -B and all mismatches for HLA-C.