uPAR expression levels, total uPA levels, and DTU2GMCSF efficacy, with or without pro-uPA, on the 12 AML cell lines that were sensitive to DT388GMCSF
Cell line . | uPAR levels, no. receptors/ cell . | Total uPA levels, ng/mL . | DTU2GMCSF, IC50, pM . | DTU2GMCSF + pro-uPA, IC50, pM . |
|---|---|---|---|---|
| TF1-vRaf | 1848 | 0.116 | 3.14 | 0.26 |
| ML2 | 784 | 0.283 | 5.8 | 0.76 |
| U937 | 480 | 0.135 | 34.7 | 0.48 |
| KG-1 | 399 | 0.326 | 9.8 | 3.5 |
| HL60 | 387 | 0.489 | 7.8 | 1.5 |
| ML1 | 991 | 0.094 | >4000 | 30 |
| TF1-HaRas | 581 | 0.092 | >4000 | 0.67 |
| TF1-vSrc | 491 | 0.054 | >4000 | 0.55 |
| Sig M5 | 241 | 0.090 | >4000 | 42 |
| ML17 | 54 | 0.294 | >4000 | 4.5 |
| Monomac 6 | 45 | 0.559 | >4000 | 1730 |
| Monomac 1 | 33 | 0.931 | >4000 | >4000 |
| CTV-1* | 110 | 0.32 | >4000 | >4000 |
Cell line . | uPAR levels, no. receptors/ cell . | Total uPA levels, ng/mL . | DTU2GMCSF, IC50, pM . | DTU2GMCSF + pro-uPA, IC50, pM . |
|---|---|---|---|---|
| TF1-vRaf | 1848 | 0.116 | 3.14 | 0.26 |
| ML2 | 784 | 0.283 | 5.8 | 0.76 |
| U937 | 480 | 0.135 | 34.7 | 0.48 |
| KG-1 | 399 | 0.326 | 9.8 | 3.5 |
| HL60 | 387 | 0.489 | 7.8 | 1.5 |
| ML1 | 991 | 0.094 | >4000 | 30 |
| TF1-HaRas | 581 | 0.092 | >4000 | 0.67 |
| TF1-vSrc | 491 | 0.054 | >4000 | 0.55 |
| Sig M5 | 241 | 0.090 | >4000 | 42 |
| ML17 | 54 | 0.294 | >4000 | 4.5 |
| Monomac 6 | 45 | 0.559 | >4000 | 1730 |
| Monomac 1 | 33 | 0.931 | >4000 | >4000 |
| CTV-1* | 110 | 0.32 | >4000 | >4000 |
This cell line was not sensitive to DT388GMCSF because of low GM-CSFR expression levels and was not included in the correlation of DTU2GMCSF efficacy with uPAR expression levels and total uPA levels.