Specification of documented infection for different levels of G-CSF responsiveness
. | 1st transplantation . | . | . | 2nd transplantation . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| G-CSF responsiveness . | Low . | Medium . | High . | Low . | Medium . | High . | ||||
| No. of patients | 17 | 17 | 16 | 12 | 12 | 11 | ||||
| No. of patients with an infection | 9 | 2 | 0 | 7 | 4 | 1 | ||||
| Specification | ||||||||||
| Blood stream infection | 4 | 2 | 0 | 3 | 3 | 0 | ||||
| Pneumonia | 4 | 0 | 0 | 4 | 1 | 0 | ||||
| Invasive fungal infection | 1 | 0 | 0 | 1 | 0 | 0 | ||||
| Severe enterocolitis | 1 | 0 | 0 | 0 | 1 | 0 | ||||
| Soft-tissue infection | 0 | 0 | 0 | 2 | 0 | 0 | ||||
| Other infections | 3 | 0 | 0 | 0 | 0 | 1 | ||||
| Treatment-related mortality | 1 | 0 | 0 | 1 | 0 | 0 | ||||
. | 1st transplantation . | . | . | 2nd transplantation . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| G-CSF responsiveness . | Low . | Medium . | High . | Low . | Medium . | High . | ||||
| No. of patients | 17 | 17 | 16 | 12 | 12 | 11 | ||||
| No. of patients with an infection | 9 | 2 | 0 | 7 | 4 | 1 | ||||
| Specification | ||||||||||
| Blood stream infection | 4 | 2 | 0 | 3 | 3 | 0 | ||||
| Pneumonia | 4 | 0 | 0 | 4 | 1 | 0 | ||||
| Invasive fungal infection | 1 | 0 | 0 | 1 | 0 | 0 | ||||
| Severe enterocolitis | 1 | 0 | 0 | 0 | 1 | 0 | ||||
| Soft-tissue infection | 0 | 0 | 0 | 2 | 0 | 0 | ||||
| Other infections | 3 | 0 | 0 | 0 | 0 | 1 | ||||
| Treatment-related mortality | 1 | 0 | 0 | 1 | 0 | 0 | ||||
Because there could be more than one documented infection in any patient, the total number of specified infections exceeds the number of patients with a documented infection. In 9 of 12 bloodstream infections, coagulase-negative staphylococci were isolated. In the subgroups with a low G-CSF responsiveness, patients were defined as having a documented infection solely by the presence of a bloodstream infection in 2 of 9 cases after the first transplantation and in 1 of 7 cases after the second transplantation.