Associations between response to imatinib mesylate at 3, 6, 12, and 15 to 18 months and later complete cytogenetic response and survival
Cytogenetic response . | No. . | No. with complete cytogenetic response (%)* . | Estimated 4-y survival, %* . |
|---|---|---|---|
| At 3 mo | |||
| Ph more than 90% | 77 | 19 (25) | 72 |
| Ph 65% to 90% | 17 | 13 (76) | 94 |
| Ph 35% to 64% | 14 | 10 (71) | 92 |
| Ph 1% to 34% | 46 | 29 (85) | 100 |
| Ph 0% | 65 | NA | 91 |
| At 6 mo | |||
| Ph more than 90% | 58 | 8 (14) | 70 |
| Ph 35% to 90% | 29 | 18 (62) | 96 |
| Ph 1% to 34% | 40 | 29 (73) | 91 |
| Ph 0% | 72 | NA | 97 |
| At 12 mo | |||
| Ph more than 90% | 41 | 3 (7) | 74 |
| Ph 35% to 90% | 16 | 10 (63) | 88 |
| Ph 1% to 34% | 34 | 24 (71) | 97 |
| Ph 0% | 89 | NA | 97 |
| At 15 to 18 mo | |||
| Ph 35% or more | 63 | 6 (10) | 79 |
| Ph 1% to 34% | 37 | 27 (73) | 94 |
| Ph 0% | 97 | NA | 97 |
Cytogenetic response . | No. . | No. with complete cytogenetic response (%)* . | Estimated 4-y survival, %* . |
|---|---|---|---|
| At 3 mo | |||
| Ph more than 90% | 77 | 19 (25) | 72 |
| Ph 65% to 90% | 17 | 13 (76) | 94 |
| Ph 35% to 64% | 14 | 10 (71) | 92 |
| Ph 1% to 34% | 46 | 29 (85) | 100 |
| Ph 0% | 65 | NA | 91 |
| At 6 mo | |||
| Ph more than 90% | 58 | 8 (14) | 70 |
| Ph 35% to 90% | 29 | 18 (62) | 96 |
| Ph 1% to 34% | 40 | 29 (73) | 91 |
| Ph 0% | 72 | NA | 97 |
| At 12 mo | |||
| Ph more than 90% | 41 | 3 (7) | 74 |
| Ph 35% to 90% | 16 | 10 (63) | 88 |
| Ph 1% to 34% | 34 | 24 (71) | 97 |
| Ph 0% | 89 | NA | 97 |
| At 15 to 18 mo | |||
| Ph 35% or more | 63 | 6 (10) | 79 |
| Ph 1% to 34% | 37 | 27 (73) | 94 |
| Ph 0% | 97 | NA | 97 |
Ph indicates Philadelphia chromosome positivity.
P < .01 for all categories of cytogenetic response and of survival.