Table 9.

Incidence of grade 3 or 4 side effects with imatinib mesylate therapy (n = 261)


Side effect

No. (%)
Nausea, vomiting   0 (0)  
Diarrhea   1 (0.4)  
Skin rashes   6 (2)  
Fluid retention   0 (0)  
Muscle cramps   0 (0)  
Bone or joint aches   3 (1)  
Liver toxicity   6 (2)  
Others*  9 (3)  
Granulocytopenia  
    Less than 1 × 109/L   118 (45)  
    Less than 0.5 × 109/L   45 (17)  
Anemia  
    Less than 8 g/dL   28 (11)  
    Less than 6.5 g/dL   9 (3)  
Thrombocytopenia  
    Less than 50 × 109/L   53 (20)  
    Less than 15 × 109/L
 
6 (2)
 

Side effect

No. (%)
Nausea, vomiting   0 (0)  
Diarrhea   1 (0.4)  
Skin rashes   6 (2)  
Fluid retention   0 (0)  
Muscle cramps   0 (0)  
Bone or joint aches   3 (1)  
Liver toxicity   6 (2)  
Others*  9 (3)  
Granulocytopenia  
    Less than 1 × 109/L   118 (45)  
    Less than 0.5 × 109/L   45 (17)  
Anemia  
    Less than 8 g/dL   28 (11)  
    Less than 6.5 g/dL   9 (3)  
Thrombocytopenia  
    Less than 50 × 109/L   53 (20)  
    Less than 15 × 109/L
 
6 (2)
 
*

One fatigue, 4 fever, 2 neurologic/depression, and 2 cardiac.

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