Candidate gene haplotype association: maximum likelihood estimates
Bleeding scores, by gene . | Minimum haplotype . | Estimate . | Maximum haplotype . | Estimate . | P . |
|---|---|---|---|---|---|
| Bleeding severity score | |||||
| ITGA2 | 3 | -0.5020 | 2 | 0.3718 | .01 |
| -92 | G | -0.0174 | C | 0.0174 | .84 |
| -52 | A | -0.0769 | G | 0.0769 | .25 |
| GP6 | a | -0.0855 | b | 0.0855 | .48 |
| GPIBA | 2 | -0.0718 | 1 | 0.0718 | .51 |
| -5 | T | -0.0417 | C | 0.0417 | .73 |
| ITGB3 | 2 | -0.1482 | 1 | 0.1482 | .11 |
| ITGA2B | 2 | -0.1698 | 1 | 0.1698 | .03 |
| VWF | 1 | -0.0584 | 2 | 0.0584 | .41 |
| IL6 | 2 | -0.0035 | 1 | 0.0035 | .96 |
| FGB | 2 | -0.0958 | 1 | 0.0958 | .23 |
| TBXA2R | 2 | -0.0088 | 1 | 0.0088 | .90 |
| Adjusted bleeding severity score, score/age | |||||
| ITGA2 | 3 | -0.4708 | 2 | 0.3374 | .01 |
| -92 | G | -0.0099 | C | 0.0099 | .93 |
| -52 | A | -0.0961 | G | 0.0961 | .28 |
| GP6 | a | -0.3312 | b | 0.3312 | .03 |
| GPIBA | 1 | -0.1263 | 2 | 0.1263 | .37 |
| -5 | C | -0.0564 | T | 0.0564 | .73 |
| ITGB3 | 2 | -0.0984 | 1 | 0.0984 | .40 |
| ITGA2B | 2 | -0.2544 | 1 | 0.2544 | .01 |
| VWF | 2 | -0.1120 | 1 | 0.1120 | .20 |
| IL6 | 1 | -0.0170 | 2 | 0.0170 | .85 |
| FGB | 2 | -0.0075 | 1 | 0.0075 | .94 |
| TBXA2R | 1 | -0.0509 | 2 | 0.0509 | .58 |
| Plasma VWF:Ag level | |||||
| ITGA2 | 1 | -0.1512 | 2 | 0.1364 | .37 |
| -92 | C | -0.1030 | G | 0.1030 | .37 |
| -52 | G | -0.0802 | A | 0.0802 | .39 |
| GP6 | b | -0.2522 | a | 0.2522 | .09 |
| GPIBA | 2 | -0.1868 | 1 | 0.1868 | .26 |
| -5 | C | -0.0307 | T | 0.0307 | .84 |
| ITGB3 | 1 | -0.0772 | 2 | 0.0772 | .52 |
| ITGA2B | 1 | -0.1572 | 2 | 0.1572 | .15 |
| VWF | 2 | -0.1939 | 1 | 0.1939 | .02 |
| IL6 | 2 | -0.0885 | 1 | 0.0885 | .38 |
| FGB | 2 | -0.0197 | 1 | 0.0197 | .84 |
| TBXA2R | 1 | -0.0480 | 2 | 0.0480 | .61 |
| Bleeding time | |||||
| ITGA2 | 3 | 0.2144 | 1 | -0.1321 | .35 |
| -92 | G | 0.0750 | C | -0.0750 | .48 |
| -52 | G | 0.0066 | A | -0.0066 | .94 |
| GP6 | a | 0.2329 | b | -0.2329 | .11 |
| GPIBA | 2 | 0.0661 | 1 | -0.0661 | .61 |
| -5 | T | 0.2418 | C | -0.2418 | .10 |
| ITGB3 | 2 | 0.1910 | 1 | -0.1910 | .07 |
| ITGA2B | 2 | 0.0673 | 1 | -0.0673 | .44 |
| VWF | 2 | 0.0482 | 1 | -0.0482 | .56 |
| IL6 | 1 | 0.1852 | 2 | -0.1852 | .12 |
| FGB | 1 | 0.0737 | 2 | -0.0737 | .40 |
| TBXA2R | 1 | 0.1132 | 2 | -0.1132 | .18 |
Bleeding scores, by gene . | Minimum haplotype . | Estimate . | Maximum haplotype . | Estimate . | P . |
|---|---|---|---|---|---|
| Bleeding severity score | |||||
| ITGA2 | 3 | -0.5020 | 2 | 0.3718 | .01 |
| -92 | G | -0.0174 | C | 0.0174 | .84 |
| -52 | A | -0.0769 | G | 0.0769 | .25 |
| GP6 | a | -0.0855 | b | 0.0855 | .48 |
| GPIBA | 2 | -0.0718 | 1 | 0.0718 | .51 |
| -5 | T | -0.0417 | C | 0.0417 | .73 |
| ITGB3 | 2 | -0.1482 | 1 | 0.1482 | .11 |
| ITGA2B | 2 | -0.1698 | 1 | 0.1698 | .03 |
| VWF | 1 | -0.0584 | 2 | 0.0584 | .41 |
| IL6 | 2 | -0.0035 | 1 | 0.0035 | .96 |
| FGB | 2 | -0.0958 | 1 | 0.0958 | .23 |
| TBXA2R | 2 | -0.0088 | 1 | 0.0088 | .90 |
| Adjusted bleeding severity score, score/age | |||||
| ITGA2 | 3 | -0.4708 | 2 | 0.3374 | .01 |
| -92 | G | -0.0099 | C | 0.0099 | .93 |
| -52 | A | -0.0961 | G | 0.0961 | .28 |
| GP6 | a | -0.3312 | b | 0.3312 | .03 |
| GPIBA | 1 | -0.1263 | 2 | 0.1263 | .37 |
| -5 | C | -0.0564 | T | 0.0564 | .73 |
| ITGB3 | 2 | -0.0984 | 1 | 0.0984 | .40 |
| ITGA2B | 2 | -0.2544 | 1 | 0.2544 | .01 |
| VWF | 2 | -0.1120 | 1 | 0.1120 | .20 |
| IL6 | 1 | -0.0170 | 2 | 0.0170 | .85 |
| FGB | 2 | -0.0075 | 1 | 0.0075 | .94 |
| TBXA2R | 1 | -0.0509 | 2 | 0.0509 | .58 |
| Plasma VWF:Ag level | |||||
| ITGA2 | 1 | -0.1512 | 2 | 0.1364 | .37 |
| -92 | C | -0.1030 | G | 0.1030 | .37 |
| -52 | G | -0.0802 | A | 0.0802 | .39 |
| GP6 | b | -0.2522 | a | 0.2522 | .09 |
| GPIBA | 2 | -0.1868 | 1 | 0.1868 | .26 |
| -5 | C | -0.0307 | T | 0.0307 | .84 |
| ITGB3 | 1 | -0.0772 | 2 | 0.0772 | .52 |
| ITGA2B | 1 | -0.1572 | 2 | 0.1572 | .15 |
| VWF | 2 | -0.1939 | 1 | 0.1939 | .02 |
| IL6 | 2 | -0.0885 | 1 | 0.0885 | .38 |
| FGB | 2 | -0.0197 | 1 | 0.0197 | .84 |
| TBXA2R | 1 | -0.0480 | 2 | 0.0480 | .61 |
| Bleeding time | |||||
| ITGA2 | 3 | 0.2144 | 1 | -0.1321 | .35 |
| -92 | G | 0.0750 | C | -0.0750 | .48 |
| -52 | G | 0.0066 | A | -0.0066 | .94 |
| GP6 | a | 0.2329 | b | -0.2329 | .11 |
| GPIBA | 2 | 0.0661 | 1 | -0.0661 | .61 |
| -5 | T | 0.2418 | C | -0.2418 | .10 |
| ITGB3 | 2 | 0.1910 | 1 | -0.1910 | .07 |
| ITGA2B | 2 | 0.0673 | 1 | -0.0673 | .44 |
| VWF | 2 | 0.0482 | 1 | -0.0482 | .56 |
| IL6 | 1 | 0.1852 | 2 | -0.1852 | .12 |
| FGB | 1 | 0.0737 | 2 | -0.0737 | .40 |
| TBXA2R | 1 | 0.1132 | 2 | -0.1132 | .18 |
Boldface indicates P < .05.