Characteristics of 182 children with ETV6/RUNX1+ or ETV6/RUNX1- precursor B-ALL excluding patients with high hyperdiploidy (> 51), t(9;22), t(1;19), and 11q23 rearrangement
ETV6/RUNX1 . | Positive . | Negative . | P . |
|---|---|---|---|
| No. of patients | 82 | 100 | |
| Median age, y (range) | 4.4 (1.3-15.6) | 6.3 (1.2-17.0) | .001 |
| Sex | .58 | ||
| Male, n (%) | 45 (55) | 59 (59) | |
| Female, n (%) | 37 (45) | 41 (41) | |
| WBC count | |||
| Median | 8 | 7 | .66 |
| Less than 10 × 109/L, n (%) | 45 (55) | 59 (59) | |
| Between 10 and 50 × 109/L, n (%) | 29 (35) | 29 (29) | |
| 50 × 109/L or more, n (%) | 8 (10) | 12 (12) |
ETV6/RUNX1 . | Positive . | Negative . | P . |
|---|---|---|---|
| No. of patients | 82 | 100 | |
| Median age, y (range) | 4.4 (1.3-15.6) | 6.3 (1.2-17.0) | .001 |
| Sex | .58 | ||
| Male, n (%) | 45 (55) | 59 (59) | |
| Female, n (%) | 37 (45) | 41 (41) | |
| WBC count | |||
| Median | 8 | 7 | .66 |
| Less than 10 × 109/L, n (%) | 45 (55) | 59 (59) | |
| Between 10 and 50 × 109/L, n (%) | 29 (35) | 29 (29) | |
| 50 × 109/L or more, n (%) | 8 (10) | 12 (12) |
Children with high hyperdiploidy (n = 81; data available in 78% of the cases), t(9;22) (n = 5; data available in 85% of the cases), t(1;19) (n = 6; data available in 50% of the cases), 11q23 rearrangement (n = 4; data available in 50% of the cases) were excluded from the cohort of 275 patients. Some patients had more than one chromosomal aberration.
P values were determined by χ2 and Mann-Whitney U test.