IC50 values for MLN518 and imatinib mesylate on samples from patients with AML and normal bone marrow
. | AML ITD-positive . | . | AML ITD-negative . | . | Normal bone marrow . | . | |||
|---|---|---|---|---|---|---|---|---|---|
| Sample . | + MLN518, nM . | + imatinib mesylate, nM . | + MLN518, nM . | + imatinib mesylate, nM . | + MLN518, nM . | + MLN518, nM . | |||
| 1 | 75 | 850 | — | — | — | — | |||
| 2 | 100 | 950 | — | — | — | — | |||
| 3 | 100 | 10 000 | — | — | — | — | |||
| 4 | 400 | — | — | — | — | — | |||
| 5 | — | — | 200 | 850 | — | — | |||
| 6 | — | — | 10 000 | — | — | — | |||
| 7 | — | — | 425 | 3400 | — | — | |||
| 8 | — | — | 10 000 | 2500 | — | — | |||
| CFU-GM | — | — | — | — | 800 | — | |||
| BFU-E | — | — | — | — | — | 500 | |||
. | AML ITD-positive . | . | AML ITD-negative . | . | Normal bone marrow . | . | |||
|---|---|---|---|---|---|---|---|---|---|
| Sample . | + MLN518, nM . | + imatinib mesylate, nM . | + MLN518, nM . | + imatinib mesylate, nM . | + MLN518, nM . | + MLN518, nM . | |||
| 1 | 75 | 850 | — | — | — | — | |||
| 2 | 100 | 950 | — | — | — | — | |||
| 3 | 100 | 10 000 | — | — | — | — | |||
| 4 | 400 | — | — | — | — | — | |||
| 5 | — | — | 200 | 850 | — | — | |||
| 6 | — | — | 10 000 | — | — | — | |||
| 7 | — | — | 425 | 3400 | — | — | |||
| 8 | — | — | 10 000 | 2500 | — | — | |||
| CFU-GM | — | — | — | — | 800 | — | |||
| BFU-E | — | — | — | — | — | 500 | |||
— indicates not applicable.