MLN518 cellular IC50 for FLT3-ITD and FLT3 activation loop mutations
. | IC50, μM . |
|---|---|
| ITD | 0.55 |
| I836del | 0.55 |
| D835E | 0.99 |
| D835A | 1.22 |
| D835N | 1.53 |
| D835H | 2.65 |
| D835del | 7.50 |
| D835V | > 10.00 |
| D835Y | > 10.00 |
. | IC50, μM . |
|---|---|
| ITD | 0.55 |
| I836del | 0.55 |
| D835E | 0.99 |
| D835A | 1.22 |
| D835N | 1.53 |
| D835H | 2.65 |
| D835del | 7.50 |
| D835V | > 10.00 |
| D835Y | > 10.00 |
Growth curves in Figure 2A were used to create computer-generated smoothed curves, from which cellular IC50 values were determined.