Expression of TCRs and molecules involved in proximal TCR signaling in ALCL and other PTCLs
. | . | . | . | . | . | ZAP-70, % . | . | . | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Diagnosis . | ALK1 . | No. . | βF1, % . | δF1, % . | CD3, % . | − . | −/+ . | + . | ||
| ALCL, systemic | + | 24 | 4 | 0 | 4 | 71 | 25 | 4 | ||
| ALCL, systemic | — | 15 | 7 | 0 | 60 | 80 | 13 | 7 | ||
| ALCL, cutaneous | — | 7 | 0 | 0 | 29 | 71 | 0 | 29 | ||
| NOS | — | 22 | 86 | 5 | 71 | 0 | 8 | 92 | ||
| AILT | — | 7 | 100 | 0 | 80 | 0 | 0 | 100 | ||
. | . | . | . | . | . | ZAP-70, % . | . | . | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Diagnosis . | ALK1 . | No. . | βF1, % . | δF1, % . | CD3, % . | − . | −/+ . | + . | ||
| ALCL, systemic | + | 24 | 4 | 0 | 4 | 71 | 25 | 4 | ||
| ALCL, systemic | — | 15 | 7 | 0 | 60 | 80 | 13 | 7 | ||
| ALCL, cutaneous | — | 7 | 0 | 0 | 29 | 71 | 0 | 29 | ||
| NOS | — | 22 | 86 | 5 | 71 | 0 | 8 | 92 | ||
| AILT | — | 7 | 100 | 0 | 80 | 0 | 0 | 100 | ||
Differences between ALCL and both PTCL-NOS and AILT are statistically significant (P < .001) for the expression of βF1 and CD3 in the ϰ2 test and for ZAP-70 expression in Spearman rank correlation test. The expression of these antigens was not significantly different between systemic and cutaneous ALCLs (P > .05). Among systemic ALCL, CD3 expression was significantly more frequent in the ALK1− than in the ALK+ group, but the expression of TCRβ and ZAP-70 was not significantly different.