Characteristics of participants in prospective studies by MTHFR C677T genotype
. | Noncarriers . | Heterozygotes . | Homozygotes . |
|---|---|---|---|
| No. | 4429 | 3961 | 848 |
| Female, % | 56 | 55 | 55 |
| Age at entry, y | 45 ± 0.2 | 45 ± 0.2 | 45 ± 0.4 |
| Cholesterol level, mmol/L | 5.8 ± 0.02 | 5.8 ± 0.02 | 5.8 ± 0.04 |
| HDL-cholesterol level, mmol/L | 1.3 ± 0.01 | 1.3 ± 0.01 | 1.3 ± 0.01 |
| Lipoprotein(a) level, mg/dL | 309 ± 6 | 313 ± 6 | 296 ± 13 |
| Fibrinogen level, g/L | 3.1 ± 0.01 | 3.1 ± 0.01 | 3.1 ± 0.03 |
| Triglyceride level, mmol/L | 1.7 ± 0.02 | 1.7 ± 0.02 | 1.7 ± 0.04 |
| Body mass index, kg/m2 | 24.5 ± 0.1 | 24.7 ± 0.1 | 24.5 ± 0.2 |
| Smoking, % | 75 | 76 | 77 |
| Diabetes mellitus, % | 3 | 4 | 3 |
| Hypertension, % | 13 | 14 | 16 |
| Factor V Leiden | |||
| Noncarrier, % | 92 | 93 | 93 |
| Heterozygote, % | 8 | 7 | 7 |
| Homozygote, % | 0.2 | 0.3 | 0 |
. | Noncarriers . | Heterozygotes . | Homozygotes . |
|---|---|---|---|
| No. | 4429 | 3961 | 848 |
| Female, % | 56 | 55 | 55 |
| Age at entry, y | 45 ± 0.2 | 45 ± 0.2 | 45 ± 0.4 |
| Cholesterol level, mmol/L | 5.8 ± 0.02 | 5.8 ± 0.02 | 5.8 ± 0.04 |
| HDL-cholesterol level, mmol/L | 1.3 ± 0.01 | 1.3 ± 0.01 | 1.3 ± 0.01 |
| Lipoprotein(a) level, mg/dL | 309 ± 6 | 313 ± 6 | 296 ± 13 |
| Fibrinogen level, g/L | 3.1 ± 0.01 | 3.1 ± 0.01 | 3.1 ± 0.03 |
| Triglyceride level, mmol/L | 1.7 ± 0.02 | 1.7 ± 0.02 | 1.7 ± 0.04 |
| Body mass index, kg/m2 | 24.5 ± 0.1 | 24.7 ± 0.1 | 24.5 ± 0.2 |
| Smoking, % | 75 | 76 | 77 |
| Diabetes mellitus, % | 3 | 4 | 3 |
| Hypertension, % | 13 | 14 | 16 |
| Factor V Leiden | |||
| Noncarrier, % | 92 | 93 | 93 |
| Heterozygote, % | 8 | 7 | 7 |
| Homozygote, % | 0.2 | 0.3 | 0 |
Values are mean ± SE or percentage of individuals. HDL indicates high-density lipoprotein. Homozygotes and heterozygotes each were compared with noncarriers using Student t test, Mann-Whitney U-test, or χ2-test. No difference between genotypes was detected.