Hazard ratios for ICD and VTE by MTHFR C677T genotype in prospective studies
. | Ischemic cardiovascular disease . | . | Venous thromboembolism . | . | ||
|---|---|---|---|---|---|---|
. | Hazard ratio (95% CI) . | Trend test, P . | Hazard ratio (95% CI) . | Trend test, P . | ||
| Sex and age adjustment | ||||||
| Noncarriers | 1.0 | .13 | 1.0 | .64 | ||
| Heterozygotes | 1.1 (1.0-1.2) | .13 | 1.1 (0.8-1.5) | .64 | ||
| Homozygotes | 1.1 (0.9-1.3) | .13 | 1.1 (0.6-1.7) | .64 | ||
| Multifactorial adjustment* | ||||||
| Noncarriers | 1.0 | .44 | 1.0 | .67 | ||
| Heterozygotes | 1.0 (0.9-1.2) | .44 | 1.1 (0.8-1.5) | .67 | ||
| Homozygotes | 1.1 (0.9-1.3) | .44 | 1.0 (0.6-1.7) | .67 | ||
. | Ischemic cardiovascular disease . | . | Venous thromboembolism . | . | ||
|---|---|---|---|---|---|---|
. | Hazard ratio (95% CI) . | Trend test, P . | Hazard ratio (95% CI) . | Trend test, P . | ||
| Sex and age adjustment | ||||||
| Noncarriers | 1.0 | .13 | 1.0 | .64 | ||
| Heterozygotes | 1.1 (1.0-1.2) | .13 | 1.1 (0.8-1.5) | .64 | ||
| Homozygotes | 1.1 (0.9-1.3) | .13 | 1.1 (0.6-1.7) | .64 | ||
| Multifactorial adjustment* | ||||||
| Noncarriers | 1.0 | .44 | 1.0 | .67 | ||
| Heterozygotes | 1.0 (0.9-1.2) | .44 | 1.1 (0.8-1.5) | .67 | ||
| Homozygotes | 1.1 (0.9-1.3) | .44 | 1.0 (0.6-1.7) | .67 | ||
Hazard ratio with 95% confidence interval (CI) was calculated with noncarriers versus heterozygotes or homozygotes using Cox regression. P values are for trend tests from noncarriers to heterozygotes to homozygotes.
Adjusted for sex, age, and medians of cholesterol, high-density lipoprotein cholesterol, lipoprotein(a), fibrinogen, triglycerides, and body mass index as well as smoking, diabetes mellitus, hypertension, and factor V Leiden genotype.