CI values for the effects of daunorubicin and SU11248 on cellular proliferation
. | ED50 . | ED75 . | ED90 . |
|---|---|---|---|
| MV4-11 | 1.22 | 1.09 | 0.98 |
| MOLM14 | 1.15 | 1.07 | 1.00 |
| BAF3 ITD FLT3 | 1.16 | 1.00 | 0.87 |
| BAF3 WT FLT3 + FL | 0.73 | 0.72 | 0.72 |
| BAF3 D835V FLT3 | 0.82 | 0.72 | 0.64 |
. | ED50 . | ED75 . | ED90 . |
|---|---|---|---|
| MV4-11 | 1.22 | 1.09 | 0.98 |
| MOLM14 | 1.15 | 1.07 | 1.00 |
| BAF3 ITD FLT3 | 1.16 | 1.00 | 0.87 |
| BAF3 WT FLT3 + FL | 0.73 | 0.72 | 0.72 |
| BAF3 D835V FLT3 | 0.82 | 0.72 | 0.64 |
CIs are near 1 for MV4-11 and MOLM14 cell lines for all effective doses for the combination, suggesting an additive effect for the combination. In contrast, CIs were significantly < 1 for ED75 and ED90 for all 3 BAF3-derived cell lines, indicating a synergistic effect for the combination.