Clinical characteristics of patients
Patient no. . | Age, y . | FAB classification . | Cytogenetics . | Sex . | BM cellularity, % . | BM blasts, % . | ANC, × 109/L . | Platelet count, × 109/L . | Cytogenetic abnormality by FISH, % . |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 46 | RAEB | 45XX, - 7 | F | 10 | 14 | 0.5 | 10 | ND |
| 2 | 72 | RAEB | 45XY, - 7 | M | 60 | 18 | 0.7 | 15 | ND |
| 3 | 71 | RAEB | 45XY, - 7 | M | 50 | 9 | 0.5 | 64 | 7 |
| 4 | 61 | RA | 45XY, - 7 | M | 50 | 3 | 0.4 | 28 | 65 |
| 5 | 61 | RAEB | 47XX, + 8 | F | 80 | 15 | 0.4 | 133 | 57 |
| 6 | 62 | RAEB | 47XX, + 8 | F | 60 | 15 | 0.6 | 8 | 45 |
| 7 | 33 | RA | 47XX, + 8 | F | 60 | 2 | 0.2 | 4 | ND |
| 8 | 41 | RA | 47XY, + 8 | M | 10 | 0 | 0.8 | 34 | 65 |
| 9 | 49 | RA | 47XX, + 8 | F | 25 | 0 | 1.9 | 75 | 57 |
| 10 | 44 | RARS | 47XX, + 8 | F | 60 | 3 | 3.7 | 310 | 45* |
| 11 | 73 | RAEB | 47XY,8 | M | 80 | 6 | 4.4 | 39 | 65 |
| 12 | 61 | RA | 47XY, + 8 | M | 60 | 0 | 0.2 | 24 | 65 |
| 13 | 56 | RA | 47XY, + 8 | M | 10 | 3 | 0.4 | 114 | 69* |
| 14 | 59 | RA | 47XX, + 8 | F | 10 | 2 | 0.6 | 15 | 16 |
| 15 | 64 | RA | 47XY, + 8 | M | 20 | 10 | 0.9 | 72 | 68 |
| 16 | 59 | RA | 47XY, + 8 | M | 40 | 2 | 1.5 | 26 | ND |
| 17 | 60 | RARS | 47XY, + 8 | M | 30 | 3 | 3.1 | 231 | 12 |
Patient no. . | Age, y . | FAB classification . | Cytogenetics . | Sex . | BM cellularity, % . | BM blasts, % . | ANC, × 109/L . | Platelet count, × 109/L . | Cytogenetic abnormality by FISH, % . |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 46 | RAEB | 45XX, - 7 | F | 10 | 14 | 0.5 | 10 | ND |
| 2 | 72 | RAEB | 45XY, - 7 | M | 60 | 18 | 0.7 | 15 | ND |
| 3 | 71 | RAEB | 45XY, - 7 | M | 50 | 9 | 0.5 | 64 | 7 |
| 4 | 61 | RA | 45XY, - 7 | M | 50 | 3 | 0.4 | 28 | 65 |
| 5 | 61 | RAEB | 47XX, + 8 | F | 80 | 15 | 0.4 | 133 | 57 |
| 6 | 62 | RAEB | 47XX, + 8 | F | 60 | 15 | 0.6 | 8 | 45 |
| 7 | 33 | RA | 47XX, + 8 | F | 60 | 2 | 0.2 | 4 | ND |
| 8 | 41 | RA | 47XY, + 8 | M | 10 | 0 | 0.8 | 34 | 65 |
| 9 | 49 | RA | 47XX, + 8 | F | 25 | 0 | 1.9 | 75 | 57 |
| 10 | 44 | RARS | 47XX, + 8 | F | 60 | 3 | 3.7 | 310 | 45* |
| 11 | 73 | RAEB | 47XY,8 | M | 80 | 6 | 4.4 | 39 | 65 |
| 12 | 61 | RA | 47XY, + 8 | M | 60 | 0 | 0.2 | 24 | 65 |
| 13 | 56 | RA | 47XY, + 8 | M | 10 | 3 | 0.4 | 114 | 69* |
| 14 | 59 | RA | 47XX, + 8 | F | 10 | 2 | 0.6 | 15 | 16 |
| 15 | 64 | RA | 47XY, + 8 | M | 20 | 10 | 0.9 | 72 | 68 |
| 16 | 59 | RA | 47XY, + 8 | M | 40 | 2 | 1.5 | 26 | ND |
| 17 | 60 | RARS | 47XY, + 8 | M | 30 | 3 | 3.1 | 231 | 12 |
FAB indicates French-American-British; ANC, absolute neutrophil account; RAEB, refractory anemia with excess of blasts; F, female; M, male; ND, not done; RA, refractory anemia; and RARS, refractory anemia with ring sideroblasts.
Patients 10 and 13 showed small numbers of 5q- cells by FISH only