Comparison of the nucleotide and amino acid sequences of the platelet reactive Fab antibody heavy chains with the closest germ line
. | . | . | . | R/S ratio (replacement-silent) . | . | |
|---|---|---|---|---|---|---|
| Clone . | Closest germ line . | Amino acid homology, % . | Nucleotide homology, % . | CDR . | FR . | |
| D4 | VH4-31 | 69 | 82 | 5.0 (10:2) | 1.9 (19:10) | |
| D6 | VH1-2 | 82 | 89 | > 8.0 (8:0) | 1.6 (8:5) | |
| D7 | VH1-69 | 87 | 94 | 4.0 (4:1) | 8.0 (8:1) | |
| L5 | VH1-8 | 76 | 89 | 7.0 (7:1) | 3.75 (15:4) | |
| L7 | VH5-51 | 83 | 91 | 1.5 (3:2) | 2.6 (13:5) | |
| L10 | VH1-8 | 91 | 96 | > 2.0 (2:0) | 2.0 (6:3) | |
| L12 | VH4-31 | 76 | 88 | 11.0 (11:1) | 2.0 (12:6) | |
| F5 | VH1-69 | 62 | 77 | 4.33 (13:3) | 3.0 (24:8) | |
. | . | . | . | R/S ratio (replacement-silent) . | . | |
|---|---|---|---|---|---|---|
| Clone . | Closest germ line . | Amino acid homology, % . | Nucleotide homology, % . | CDR . | FR . | |
| D4 | VH4-31 | 69 | 82 | 5.0 (10:2) | 1.9 (19:10) | |
| D6 | VH1-2 | 82 | 89 | > 8.0 (8:0) | 1.6 (8:5) | |
| D7 | VH1-69 | 87 | 94 | 4.0 (4:1) | 8.0 (8:1) | |
| L5 | VH1-8 | 76 | 89 | 7.0 (7:1) | 3.75 (15:4) | |
| L7 | VH5-51 | 83 | 91 | 1.5 (3:2) | 2.6 (13:5) | |
| L10 | VH1-8 | 91 | 96 | > 2.0 (2:0) | 2.0 (6:3) | |
| L12 | VH4-31 | 76 | 88 | 11.0 (11:1) | 2.0 (12:6) | |
| F5 | VH1-69 | 62 | 77 | 4.33 (13:3) | 3.0 (24:8) | |
R/S ratio indicates replacement-to-silent mutation ratio.