Table 2.

Frequency of dystrophin and utrophin protein before transplantation, after G-CSF administration, and at necropsy in the muscle fibers of xmd HC transplant recipients as determined by immunofluorescence

% dystrophin-positive fibers
Dystrophin background and recipient no.
After HCT
% utrophin-positive fibers before HCT
Before HCT
3 mo
After G-CSF
Necropsy
Low      
   G019   0   0   0   0.07   90  
   G123   0.23   0.08   0.41   0.03   75  
   G141   0.05   0   0.04   ND   80  
   G142   0.15   0.56   0.09   ND   85  
High      
   G121   60   ND   ND   20   87  
   G122   50   ND   ND   50   90  
   G125
 		 30
 		 ND
 		 ND
 		 30
 		 88
 
% dystrophin-positive fibers
Dystrophin background and recipient no.
After HCT
% utrophin-positive fibers before HCT
Before HCT
3 mo
After G-CSF
Necropsy
Low      
   G019   0   0   0   0.07   90  
   G123   0.23   0.08   0.41   0.03   75  
   G141   0.05   0   0.04   ND   80  
   G142   0.15   0.56   0.09   ND   85  
High      
   G121   60   ND   ND   20   87  
   G122   50   ND   ND   50   90  
   G125
 		 30
 		 ND
 		 ND
 		 30
 		 88
 

HCT indicates hematopoietic cell transplantation; G-CSF, granulocyte colony-stimulating factor; and ND, not determined.

Dystrophin and utrophin expression were examined by immunofluorescence. Mouse anti–human dystrophin and rabbit anti–human utrophin antibodies were used.

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