Incidence of LYL1, LMO2 and TAL1 and LMO1 transcript positivity in T-ALL by stage of maturation arrest
. | No. . | LYL1, % . | LMO2, % . | TAL1, % . | LMO1*, % . | None, % . |
|---|---|---|---|---|---|---|
| αβ lineage MG- | 41 | 20 | 17 | 44 | 17 | 20 |
| SIL-TAL | 20 | 15 | 25 | 85 | 10 | 0 |
| HOX11 | 19 | 28 | 6 | 17 | 0 | 74 |
| HOX11L2 | 28 | 43 | 18 | 11 | 0 | 50 |
| CALM-AF10 | 19 | 53 | 37 | 5 | 0 | 26 |
| TCRγδ MG- | 16 | 25 | 38 | 31 | 6 | 50 |
| IMγ MG- | 8 | 38 | 25 | 13 | 0 | 50 |
| IMδ MG- | 11 | 55 | 73 | 27 | 9 | 9 |
| IM0 MG- | 11 | 82 | 91 | 9 | 18 | 9 |
| Total | 173 | 35 | 31 | 30 | 8 | 32 |
. | No. . | LYL1, % . | LMO2, % . | TAL1, % . | LMO1*, % . | None, % . |
|---|---|---|---|---|---|---|
| αβ lineage MG- | 41 | 20 | 17 | 44 | 17 | 20 |
| SIL-TAL | 20 | 15 | 25 | 85 | 10 | 0 |
| HOX11 | 19 | 28 | 6 | 17 | 0 | 74 |
| HOX11L2 | 28 | 43 | 18 | 11 | 0 | 50 |
| CALM-AF10 | 19 | 53 | 37 | 5 | 0 | 26 |
| TCRγδ MG- | 16 | 25 | 38 | 31 | 6 | 50 |
| IMγ MG- | 8 | 38 | 25 | 13 | 0 | 50 |
| IMδ MG- | 11 | 55 | 73 | 27 | 9 | 9 |
| IM0 MG- | 11 | 82 | 91 | 9 | 18 | 9 |
| Total | 173 | 35 | 31 | 30 | 8 | 32 |
Transcript positivity was defined as being superior to the higher of 10% of mean normal bone marrow or thymic samples. Among TAL1- expressing cases, 8 of 10 children, 6 of 15 adolescents, and 3 of 16 adults demonstrated a SIL-TAL1 deletion.
Four patients (identified by ND in Figure 4B) were not analyzed for LMO1