Toxicity of induction therapy
Toxicity . | % grade 3 or 4 events . |
|---|---|
| CNS | 7 |
| Cerebellar | 2 |
| Cardiac | 3 |
| Cutaneous | 4 |
| Ocular | 6 |
| Stomatitis | 22 |
| Nausea and vomiting | 32 |
| Diarrhea | 34 |
| GIT* | 11 |
| Renal | 4 |
| Hepatic-bilirubin | 11 |
Toxicity . | % grade 3 or 4 events . |
|---|---|
| CNS | 7 |
| Cerebellar | 2 |
| Cardiac | 3 |
| Cutaneous | 4 |
| Ocular | 6 |
| Stomatitis | 22 |
| Nausea and vomiting | 32 |
| Diarrhea | 34 |
| GIT* | 11 |
| Renal | 4 |
| Hepatic-bilirubin | 11 |
Toxicities are serious (grades 3 and 4) nonhematologic toxicities as defined by World Health Organization (WHO) criteria.
CNS indicates central nervous system.
Additional toxicity criterion created for this study to define serious gastrointestinal toxicities of therapy: grade 3 defined as severe pain, ileus; grade 4, life-threatening GIT bleeding, diarrhea, perforation.