Nonhematologic side effects
. | No. (%) . | . | |
|---|---|---|---|
| Side effect . | Grade 1 or 2 . | Grade 3 or higher . | |
| Phase 1 | |||
| Nausea/vomiting | 11 (92) | — | |
| Diarrhea | 8 (67) | 1 (8)* | |
| Impaired liver function† | 8 (67) | — | |
| Skin rash | 6 (50) | 1 (8)* | |
| Mucositis | 5 (42) | — | |
| Facial flushing | 5 (42) | — | |
| Fatigue | 3 (25) | — | |
| Headaches | 2 (17) | — | |
| Palpitations/arrhythmias | 1 (8) | — | |
| Phase 2 | |||
| Impaired liver function† | 16 (80) | 2 (10) | |
| Nausea/vomiting | 14 (70) | — | |
| Skin rash | 12 (60) | 2 (10) | |
| Diarrhea | 10 (50) | 4 (20) | |
| Hand-foot syndrome | 9 (45) | 1 (5) | |
| Mucositis | 7 (35) | — | |
| Headaches | 7 (35) | — | |
| Facial flushing | 3 (15) | — | |
| Fatigue | 2 (10) | — | |
| Palpitations/arrhythmias | 1 (5) | 1 (5) | |
| Drug fever | 1 (5) | — | |
. | No. (%) . | . | |
|---|---|---|---|
| Side effect . | Grade 1 or 2 . | Grade 3 or higher . | |
| Phase 1 | |||
| Nausea/vomiting | 11 (92) | — | |
| Diarrhea | 8 (67) | 1 (8)* | |
| Impaired liver function† | 8 (67) | — | |
| Skin rash | 6 (50) | 1 (8)* | |
| Mucositis | 5 (42) | — | |
| Facial flushing | 5 (42) | — | |
| Fatigue | 3 (25) | — | |
| Headaches | 2 (17) | — | |
| Palpitations/arrhythmias | 1 (8) | — | |
| Phase 2 | |||
| Impaired liver function† | 16 (80) | 2 (10) | |
| Nausea/vomiting | 14 (70) | — | |
| Skin rash | 12 (60) | 2 (10) | |
| Diarrhea | 10 (50) | 4 (20) | |
| Hand-foot syndrome | 9 (45) | 1 (5) | |
| Mucositis | 7 (35) | — | |
| Headaches | 7 (35) | — | |
| Facial flushing | 3 (15) | — | |
| Fatigue | 2 (10) | — | |
| Palpitations/arrhythmias | 1 (5) | 1 (5) | |
| Drug fever | 1 (5) | — | |