The sensitivity and specificity of liver R2 for biopsy LIC prediction
LIC threshold, mg Fe/g dry weight (μmol Fe/g dry weight) . | Clinical relevance . | Sensitivity (95% confidence limits) . | Specificity (95% confidence limits) . | Area under ROC plot (SE) . |
|---|---|---|---|---|
| 1.8 (32) | Upper 95% of normal19 | 0.94 (0.86-0.97) | 1.00 (0.88-1.00) | 0.991 (0.008) |
| 3.2 (57) | Suggested lower limit of optimal range for LICs for chelation therapy in transfusional Fe overload20 | 0.94 (0.85-0.98) | 1.00 (0.91-1.00) | 0.988 (0.010) |
| 7.0 (125) | Suggested upper limit of optimal range for LICs for transfusional Fe overload and threshold for increased risk of iron-induced complications20 | 0.89 (0.79-0.95) | 0.96 (0.86-0.99) | 0.991 (0.009) |
| 15.0 (269) | Threshold for greatly increased risk for cardiac disease and early death in patients with transfusional iron overload20 | 0.85 (0.70-0.94) | 0.92 (0.83-0.96) | 0.982 (0.0016) |
LIC threshold, mg Fe/g dry weight (μmol Fe/g dry weight) . | Clinical relevance . | Sensitivity (95% confidence limits) . | Specificity (95% confidence limits) . | Area under ROC plot (SE) . |
|---|---|---|---|---|
| 1.8 (32) | Upper 95% of normal19 | 0.94 (0.86-0.97) | 1.00 (0.88-1.00) | 0.991 (0.008) |
| 3.2 (57) | Suggested lower limit of optimal range for LICs for chelation therapy in transfusional Fe overload20 | 0.94 (0.85-0.98) | 1.00 (0.91-1.00) | 0.988 (0.010) |
| 7.0 (125) | Suggested upper limit of optimal range for LICs for transfusional Fe overload and threshold for increased risk of iron-induced complications20 | 0.89 (0.79-0.95) | 0.96 (0.86-0.99) | 0.991 (0.009) |
| 15.0 (269) | Threshold for greatly increased risk for cardiac disease and early death in patients with transfusional iron overload20 | 0.85 (0.70-0.94) | 0.92 (0.83-0.96) | 0.982 (0.0016) |
The sensitivity and specificity of liver R2 measurements for discrimination of needle biopsy iron assay values above certain clinically important LIC thresholds are given together with their 95% confidence limits. The area under the ROC plot is given for each clinically important LIC threshold together with an SE calculated by the method of Hanley and McNeil16 to give an approximate estimate of the uncertainty on the area.