Efficiency of the first platelet transfusion in patients with thrombocytopenia receiving single or double doses of platelets
. | Total (n = 96) . | . | . | AL patients (n = 29) . | . | . | AT patients (n = 67) . | . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
. | Single dose . | Double dose . | P . | Single dose . | Double dose . | P . | Single dose . | Double dose . | P . | ||||||
| Platelet count increment, 109/L | 20.8 ± 13.5 | 44.5 ± 23.5 | .001 | 22.6 ± 17.8 | 43.0 ± 18.4 | .008 | 19.8 ± 10.4 | 45.0 ± 25.1 | .001 | ||||||
| CCI | 10.6 ± 5.4 | 12.5 ± 5.8 | .116 | 12.3 ± 7.7 | 12.0 ± 5.2 | .896 | 9.6 ± 3.6 | 12.6 ± 6.0 | .025 | ||||||
. | Total (n = 96) . | . | . | AL patients (n = 29) . | . | . | AT patients (n = 67) . | . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
. | Single dose . | Double dose . | P . | Single dose . | Double dose . | P . | Single dose . | Double dose . | P . | ||||||
| Platelet count increment, 109/L | 20.8 ± 13.5 | 44.5 ± 23.5 | .001 | 22.6 ± 17.8 | 43.0 ± 18.4 | .008 | 19.8 ± 10.4 | 45.0 ± 25.1 | .001 | ||||||
| CCI | 10.6 ± 5.4 | 12.5 ± 5.8 | .116 | 12.3 ± 7.7 | 12.0 ± 5.2 | .896 | 9.6 ± 3.6 | 12.6 ± 6.0 | .025 | ||||||
After the first transfusion, patients receiving a double dose of platelets had increased platelet count increments. CCI was calculated as a median time (time from the first transfusion to the next platelet count control) of 23 hours 45 minutes (minimum, 5 hours 56 minutes; maximum, 26 hours 45 minutes) for the arm A group (single dose) and 24 hours 00 minutes (minimum, 11 hours 30 minutes; maximum, 29 hours 00 minutes) for the arm B group (double dose; P = .097). With a double dose, the CCI was increased only in patients with AT but remained within a normal range (> 7), which demonstrates good efficiency in every group. Results are expressed as mean ± SD. Because of missing data, analyses were performed in 90 patients for the platelet count increment and 89 for the CCI.