Incidence of the maximum grade of mucositis according to patients receiving MTX as 4-hour intravenous infusion compared with patients receiving MTX as 24-hour intravenous infusion
. | R1 . | . | R2 . | . | R3 + R4 . | . | |||
|---|---|---|---|---|---|---|---|---|---|
| . | 1 g/m2 MTX . | . | 1 g/m2 MTX . | . | 5 g/m2 MTX . | . | |||
. | 4 h* . | 24 h* . | 4 h* . | 24 h* . | 4 h* . | 24 h* . | |||
| No. MTX-containing courses | 2 | 2 | 4 | 4 | 4 | 4 | |||
| No. of patients evaluable | 20 | 20 | 86 | 94 | 60 | 71 | |||
| % patients with maximal mucositis grade | |||||||||
| 0 | 35 | 30 | 26 | 15 | 8 | 1 | |||
| I | 45 | 15 | 27 | 13 | 15 | 4 | |||
| II | 15 | 15 | 26 | 28 | 20 | 16 | |||
| III | 5 | 25 | 16 | 22 | 32 | 36 | |||
| IV | 0 | 15 | 6 | 22 | 25 | 43 | |||
. | R1 . | . | R2 . | . | R3 + R4 . | . | |||
|---|---|---|---|---|---|---|---|---|---|
| . | 1 g/m2 MTX . | . | 1 g/m2 MTX . | . | 5 g/m2 MTX . | . | |||
. | 4 h* . | 24 h* . | 4 h* . | 24 h* . | 4 h* . | 24 h* . | |||
| No. MTX-containing courses | 2 | 2 | 4 | 4 | 4 | 4 | |||
| No. of patients evaluable | 20 | 20 | 86 | 94 | 60 | 71 | |||
| % patients with maximal mucositis grade | |||||||||
| 0 | 35 | 30 | 26 | 15 | 8 | 1 | |||
| I | 45 | 15 | 27 | 13 | 15 | 4 | |||
| II | 15 | 15 | 26 | 28 | 20 | 16 | |||
| III | 5 | 25 | 16 | 22 | 32 | 36 | |||
| IV | 0 | 15 | 6 | 22 | 25 | 43 | |||
Per protocol analysis as MTX given. Wilcoxon test P = .06 for R1, .0002 for R2, and .0027 for R3 + R4.
Indicates the number of hours over which the infusion was given.