Table 12. Percent courses with toxicity... | American Society of Hematology

Table 12.

Percent courses with toxicity grade III/IV (NCI-CTC) of randomized patients (MTX IV infusion as given)

	R1 + R2							R3 + R4
	Courses A/B							Courses AA/BB
	1 g/m² MTX							5 g/m² MTX
	4 h*†			24 h*‡			4 h*§			24 h*∥			CC¶
	Grade III toxicity %	Grade IV toxicity %	Grade III toxicity %	Grade IV toxicity %	Grade III toxicity %	Grade IV toxicity %	Grade III toxicity %	Grade IV toxicity %	Grade III toxicity %	Grade IV toxicity %
Performance status	3	1	8	1	11	5	23	6	10	2
Hemoglobin	21	8	28	9	40	13	39	24	56	17
WBC	36	37	25	49	26	48	17	69	9	87
Platelets	21	10	18	12	20	28	18	44	12	75
Infection	2	0	3	0	3	1	9	2	9	1
Mucositis	5	1	11	7	16	9	25	19	7	4
Diarrhea	1	1	0	0	2	3	5	3	3	2
Bilirubin	1	0	1	0	3	1	3	1	3	1
Central neurotoxicity	0	0	0	0	0	1	1	0	0	0

	R1 + R2							R3 + R4
	Courses A/B							Courses AA/BB
	1 g/m² MTX							5 g/m² MTX
	4 h*†			24 h*‡			4 h*§			24 h*∥			CC¶
	Grade III toxicity %	Grade IV toxicity %	Grade III toxicity %	Grade IV toxicity %	Grade III toxicity %	Grade IV toxicity %	Grade III toxicity %	Grade IV toxicity %	Grade III toxicity %	Grade IV toxicity %
Performance status	3	1	8	1	11	5	23	6	10	2
Hemoglobin	21	8	28	9	40	13	39	24	56	17
WBC	36	37	25	49	26	48	17	69	9	87
Platelets	21	10	18	12	20	28	18	44	12	75
Infection	2	0	3	0	3	1	9	2	9	1
Mucositis	5	1	11	7	16	9	25	19	7	4
Diarrhea	1	1	0	0	2	3	5	3	3	2
Bilirubin	1	0	1	0	3	1	3	1	3	1
Central neurotoxicity	0	0	0	0	0	1	1	0	0	0

NCI-CTC indicates National Cancer Institute-Common Toxicity Criteria.

Hepatotoxicity grade III/IV was 0% for all courses.

Indicates the number of hours over which the infusion was given.

374 courses recorded.

409 courses recorded.

235 courses recorded.

286 courses recorded.

165 courses recorded.