Table 1.

PML and TRAIL induction following IFN-α treatment of MM lines


MM cell line

Growth inhibition response

Induction of PML

TRAIL protein expression
OPM1   No   No   No  
OPM2   No   No   No  
XG1   No   No   No  
Delta47   No   No   No  
ANBL6   Yes   Yes   Yes  
MM144   Yes   Yes   Yes  
H929   Yes   Yes   Yes  
8226   Yes   Yes   Yes  
XG2
 
Yes
 
Yes
 
Yes
 

MM cell line

Growth inhibition response

Induction of PML

TRAIL protein expression
OPM1   No   No   No  
OPM2   No   No   No  
XG1   No   No   No  
Delta47   No   No   No  
ANBL6   Yes   Yes   Yes  
MM144   Yes   Yes   Yes  
H929   Yes   Yes   Yes  
8226   Yes   Yes   Yes  
XG2
 
Yes
 
Yes
 
Yes
 

MM cell lines were treated with or without 2000 U/mL IFN-α for 48 hours. Growth inhibition was measured by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulphenyl)-2H-tetrazolium (MTS) assay as described in “Materials and methods.” PML induction was assessed by Western blot and confocal image analysis. TRAIL was detected by Western blotting.

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