Intraindividual variation in serum Cbl and metabolites
Measurement . | No. . | Intraindividual variation (median)* . | Percent variation (median)*† . |
|---|---|---|---|
| Cbl, pg/mL | |||
| All patients | 304 | 66 ± 63 (47) | 23 ± 21 (16) |
| Range | — | 0-291 | 0-119 |
| High MMA‡ | |||
| Less than 251 nmol/L | 32 | 24 ± 30 (14) | 18 ± 29 (9) |
| Greater than 250 nmol/L | 99 | 75 ± 65 (60) | 24 ± 24 (16) |
| Greater than 376 nmol/L | 55 | 104 ± 72 (96) | 26 ± 21 (21) |
| All patients | 131 | 63 ± 53 (47) | 23 ± 21 (16) |
| Range | — | 0-280 | 0-146 |
| High HCys§ | |||
| Less than 12.2 μmol/L | 42 | 1.3 ± 1.0 (1.0) | 17 ± 14 (15) |
| Greater than 12.1 μmol/L | 64 | 2.2 ± 2.1 (1.6) | 16 ± 18 (11) |
| Greater than 13.6 μmol/L | 51 | 2.5 ± 2.3 (1.8) | 18 ± 20 (12) |
| All patients | 106 | 1.8 ± 1.8 (1.5) | 17 ± 17 (14) |
| Range | — | 0-11.0 | 0-121 |
Measurement . | No. . | Intraindividual variation (median)* . | Percent variation (median)*† . |
|---|---|---|---|
| Cbl, pg/mL | |||
| All patients | 304 | 66 ± 63 (47) | 23 ± 21 (16) |
| Range | — | 0-291 | 0-119 |
| High MMA‡ | |||
| Less than 251 nmol/L | 32 | 24 ± 30 (14) | 18 ± 29 (9) |
| Greater than 250 nmol/L | 99 | 75 ± 65 (60) | 24 ± 24 (16) |
| Greater than 376 nmol/L | 55 | 104 ± 72 (96) | 26 ± 21 (21) |
| All patients | 131 | 63 ± 53 (47) | 23 ± 21 (16) |
| Range | — | 0-280 | 0-146 |
| High HCys§ | |||
| Less than 12.2 μmol/L | 42 | 1.3 ± 1.0 (1.0) | 17 ± 14 (15) |
| Greater than 12.1 μmol/L | 64 | 2.2 ± 2.1 (1.6) | 16 ± 18 (11) |
| Greater than 13.6 μmol/L | 51 | 2.5 ± 2.3 (1.8) | 18 ± 20 (12) |
| All patients | 106 | 1.8 ± 1.8 (1.5) | 17 ± 17 (14) |
| Range | — | 0-11.0 | 0-121 |
Values are means ± 1 SD for the differences between 2 consecutive values in each patient.
Percent variation was calculated as the difference between 2 consecutive values divided by the lowest value obtained and then multiplied by 100.
Excludes 5 outliers with high MMA values above 560 nmol/L and changes of MMA above 340 nmol/L on repeat determinations.
Excludes 2 outliers with high HCys values of 99.3 and 60.7 and changes of 36.3 and 20.3, respectively, on repeat determinations.