Table 2. Comparison of the features of... | American Society of Hematology

Table 2.

Comparison of the features of apoptosis induced by p21-IRS, staurosporine, CH11, and granulysin

	p21-IRS	Staurosporine	CH11	Granulysin
Δψ_m	No change	↓	↓	↓
Apoptosis in cells overexpressing Bcl-2	No change	↓	↓	↓
Apoptosis in cells overexpressing CrmA	No change	↓	↓	↓
Activation of caspase-9	No	Yes	Yes	Yes
Apoptosis in cells treated with Z-VAD	No change	↓	↓	↓
Release of cytochrome C and AIF	Yes	Yes	Yes	Yes
Cytosolic Ca²⁺	↑	↑	↑	↑
Mitochondrial Ca²⁺	↓	↑	↑	↑
ROS	↑	↑	↑	↑
Apoptosis in cells treated with LNAC/MnTBAP	↓	↓	↓	↓
Apoptosis in cells treated with iberiotoxin	↓	No change	No change	No change
Apoptosis in cells treated with Ca²⁺ channel blockers	↓	↓	No change	↓
Apoptosis in cells treated with K⁺ channel blockers	↓	No change	No change	↓
Apoptosis in cells treated with Na⁺ channel blockers	↓	↓	No change	↓

	p21-IRS	Staurosporine	CH11	Granulysin
Δψ_m	No change	↓	↓	↓
Apoptosis in cells overexpressing Bcl-2	No change	↓	↓	↓
Apoptosis in cells overexpressing CrmA	No change	↓	↓	↓
Activation of caspase-9	No	Yes	Yes	Yes
Apoptosis in cells treated with Z-VAD	No change	↓	↓	↓
Release of cytochrome C and AIF	Yes	Yes	Yes	Yes
Cytosolic Ca²⁺	↑	↑	↑	↑
Mitochondrial Ca²⁺	↓	↑	↑	↑
ROS	↑	↑	↑	↑
Apoptosis in cells treated with LNAC/MnTBAP	↓	↓	↓	↓
Apoptosis in cells treated with iberiotoxin	↓	No change	No change	No change
Apoptosis in cells treated with Ca²⁺ channel blockers	↓	↓	No change	↓
Apoptosis in cells treated with K⁺ channel blockers	↓	No change	No change	↓
Apoptosis in cells treated with Na⁺ channel blockers	↓	↓	No change	↓

↓ indicates a decrease compared with medium; ↑, an increase compared with medium.