Heavy-and light-chain CDR3 amino acid sequences of the IGHV3-21-using CLL cases
Case . | HCDR3 AA sequence . | IG light chain gene . | LCDR3 AA sequence . |
|---|---|---|---|
| Cases with consensus sequence* | |||
| Ita3 | ARDANAMDV | Vλ2-14 (IGLV3-21) | QVWDSGSDHPWV |
| Ita4 | ...G.G... | Vλ2-14 (IGLV3-21) | ............ |
| Ita1 | ...M..... | Vλ2-14 (IGLV3-21) | ............ |
| Gre1 | .I.R.G... | Vλ2-14 (IGLV3-21) | .....S...... |
| Spa1 | .T.R.G... | Vλ2-14 (IGLV3-21) | ............ |
| Fra1 | ....DG... | Vλ2-14 (IGLV3-21) | .....S...... |
| Fra3 | ......... | IGKV3-15 | QQYNNWPPET |
| Cases with completely unrelated sequence† | |||
| Fra4 | ARDRTYPDAYFDF | IGKV3D-15 | QQYYNVWPPGR |
| Gre3 | AKDYDSSGANFQH | IGLV1-51 | GTWDTSLSAWL |
| Ita2 | ARVGNYDRYFFDF | IGKV1-12 | QQANSFPYS |
| Gre5 | ARIWDIVVVPDAMIWA | IGKV1-27 | QKYNSAQFT |
| Gre4 | ARDRRSIVVVVAATPVY | IGKV4-1 | QQSYSTLVEA |
| Fra2 | ATSGKDTTMVQGGHFDY | Vλ2-14 (IGLV3-21) | QVWDSSSDHPFV |
| Gre7 | ASQLWFDRVNNYYYMDV | IGKV1-33/1D-33 | QQYDNLPRYT |
| Gre2 | AREPLSVLLWFGESFGGGFDY | Vλ2-14 (IGLV3-21) | QVWDSGSDHPWV |
| Gre6 | ARDRLLGYCSSTSCWDYYYYYGMDV | IGKV1-17 | LQHNSYPWYT |
Case . | HCDR3 AA sequence . | IG light chain gene . | LCDR3 AA sequence . |
|---|---|---|---|
| Cases with consensus sequence* | |||
| Ita3 | ARDANAMDV | Vλ2-14 (IGLV3-21) | QVWDSGSDHPWV |
| Ita4 | ...G.G... | Vλ2-14 (IGLV3-21) | ............ |
| Ita1 | ...M..... | Vλ2-14 (IGLV3-21) | ............ |
| Gre1 | .I.R.G... | Vλ2-14 (IGLV3-21) | .....S...... |
| Spa1 | .T.R.G... | Vλ2-14 (IGLV3-21) | ............ |
| Fra1 | ....DG... | Vλ2-14 (IGLV3-21) | .....S...... |
| Fra3 | ......... | IGKV3-15 | QQYNNWPPET |
| Cases with completely unrelated sequence† | |||
| Fra4 | ARDRTYPDAYFDF | IGKV3D-15 | QQYYNVWPPGR |
| Gre3 | AKDYDSSGANFQH | IGLV1-51 | GTWDTSLSAWL |
| Ita2 | ARVGNYDRYFFDF | IGKV1-12 | QQANSFPYS |
| Gre5 | ARIWDIVVVPDAMIWA | IGKV1-27 | QKYNSAQFT |
| Gre4 | ARDRRSIVVVVAATPVY | IGKV4-1 | QQSYSTLVEA |
| Fra2 | ATSGKDTTMVQGGHFDY | Vλ2-14 (IGLV3-21) | QVWDSSSDHPFV |
| Gre7 | ASQLWFDRVNNYYYMDV | IGKV1-33/1D-33 | QQYDNLPRYT |
| Gre2 | AREPLSVLLWFGESFGGGFDY | Vλ2-14 (IGLV3-21) | QVWDSGSDHPWV |
| Gre6 | ARDRLLGYCSSTSCWDYYYYYGMDV | IGKV1-17 | LQHNSYPWYT |
Seven cases showed a consensus HCDR3 sequence or a high homology to it, differing by 1, 2, or 3 amino acids at different positions (common-HCDR3 subset), whereas 6 of 7 had a consensus LCDR3 sequence, differing by 1 amino acid in 2 cases. The remaining 9 patients expressed a completely unrelated sequence (nonhomogeneous-HCDR3 subset). Dots indicate homology.
Common-HCDR3 subset.
Nonhomogeneous HCDR3 subset.