Table 6. Characteristics of the... | American Society of Hematology

Table 6.

Characteristics of the IGHV3-21—expressing CLL patients belonging to the nonhomogeneous-HCDR3 subset

	Fra2	Fra4	Gre2	Gre3	Gre4	Gre5	Gre6	Gre7	Ita2
No. of cases	1	1	1	1	1	1	1	1	1
Age, y	54	85	65	67	70	60	81	70	86
Sex	M	F	F	F	F	M	F	M	M
IGHJ gene	IGHJ4	IGHJ4	IGHJ4	IGHJ5	IGHJ4	IGHJ4	IGHJ6	IGHJ6	IGHJ4
IGHV homology, %	98.3	93.2	99.0	94.6	97.6	98.0	99.0	98.6	92.9
LC	V_λ2-14	IGKV3D-15	V_λ2-14	IGLV1-51	IGKV4-1	IGKV1-27	IGKV1-1	IGKV1-33	IGKV1-12
IGJ LC gene	IGLJ1	IGKJ1	IGLJ3	IGLJ3	IGKJ3	IGKJ3	IGKJ2	IGKJ2	IGKJ2
IGV LC homology, %	100	97.0	100	98.3	100	99.0	100	100	96.5
CD38, %	35	ND	37	2.5	1.4	12	27	3.2	0.5
Stage at diagnosis	B	A	A	A	A	A	C	A	A
Progression	Yes	Yes	No	No	Yes	No	Yes	No	No
Need for treatment	Yes	Yes	No	No	Yes	No	Yes	No	No
CLL-related death	No	Yes	No	No	No	No	No	No	No

	Fra2	Fra4	Gre2	Gre3	Gre4	Gre5	Gre6	Gre7	Ita2
No. of cases	1	1	1	1	1	1	1	1	1
Age, y	54	85	65	67	70	60	81	70	86
Sex	M	F	F	F	F	M	F	M	M
IGHJ gene	IGHJ4	IGHJ4	IGHJ4	IGHJ5	IGHJ4	IGHJ4	IGHJ6	IGHJ6	IGHJ4
IGHV homology, %	98.3	93.2	99.0	94.6	97.6	98.0	99.0	98.6	92.9
LC	V_λ2-14	IGKV3D-15	V_λ2-14	IGLV1-51	IGKV4-1	IGKV1-27	IGKV1-1	IGKV1-33	IGKV1-12
IGJ LC gene	IGLJ1	IGKJ1	IGLJ3	IGLJ3	IGKJ3	IGKJ3	IGKJ2	IGKJ2	IGKJ2
IGV LC homology, %	100	97.0	100	98.3	100	99.0	100	100	96.5
CD38, %	35	ND	37	2.5	1.4	12	27	3.2	0.5
Stage at diagnosis	B	A	A	A	A	A	C	A	A
Progression	Yes	Yes	No	No	Yes	No	Yes	No	No
Need for treatment	Yes	Yes	No	No	Yes	No	Yes	No	No
CLL-related death	No	Yes	No	No	No	No	No	No	No