Table 6. Multivariate analysis of... | American Society of Hematology

Table 6.

Multivariate analysis of treatment failure for patients 20 and older

Variables	N	Relative risk (95% CI)	P
0-3 mo after transplantation^*			< .001†
Japanese	562	1.00	NA
White American	805	2.42 (1.68-3.49)	< .001‡
African American	67	4.47 (2.49-8.05)	< .001‡
Scandinavian	188	0.92 (0.48-1.76)	.99‡
Irish	93	1.97 (1.01-3.86)	.48‡
More than 3 mo after transplantation			.34†
Japanese	524	1.00	NA
White American	683	0.88 (0.72-1.09)	.99‡
African American	51	0.87 (0.48-1.56)	.99‡
Scandinavian	176	0.74 (0.54-1.01)	.61‡
Irish	80	0.76 (0.47-1.22)	.99‡
Age at transplantation, y
20-40	935	1.00	NA
Older than 40	780	1.44 (1.23-1.68)	< .001
Disease type			< .001§
CML	891	1.00	NA
ALL	268	1.96 (1.59-2.42)	< .001
AML	556	1.11 (0.93-1.33)	.26
Year of transplantation
1990-1994	901	1.00	NA
1995-1999	814	0.81 (0.69-0.95)	.01

Variables	N	Relative risk (95% CI)	P
0-3 mo after transplantation^*			< .001†
Japanese	562	1.00	NA
White American	805	2.42 (1.68-3.49)	< .001‡
African American	67	4.47 (2.49-8.05)	< .001‡
Scandinavian	188	0.92 (0.48-1.76)	.99‡
Irish	93	1.97 (1.01-3.86)	.48‡
More than 3 mo after transplantation			.34†
Japanese	524	1.00	NA
White American	683	0.88 (0.72-1.09)	.99‡
African American	51	0.87 (0.48-1.56)	.99‡
Scandinavian	176	0.74 (0.54-1.01)	.61‡
Irish	80	0.76 (0.47-1.22)	.99‡
Age at transplantation, y
20-40	935	1.00	NA
Older than 40	780	1.44 (1.23-1.68)	< .001
Disease type			< .001§
CML	891	1.00	NA
ALL	268	1.96 (1.59-2.42)	< .001
AML	556	1.11 (0.93-1.33)	.26
Year of transplantation
1990-1994	901	1.00	NA
1995-1999	814	0.81 (0.69-0.95)	.01

NA indicates not applicable.

Other significant comparisons:

Scandinavian vs white American (less than 3 mo): RR = 0.38; 95% CI, 0.21-0.69; P = .014‡
Scandinavian vs African American (less than 3 mo): RR = 0.21; 95% CI, 0.10-0.44; P < .001‡

Time-dependent covariate, such that risk for TRM varied before and 3 months after transplantation.

4 degrees of freedom test.

Adjusted for 10 multiple comparisons.

2 degrees of freedom test.