Molecules identified as playing a critical role in [Fe-S] cluster biogenesis
Protein . | Function . |
|---|---|
| NiFS | Azotobacter vinlandii cysteine desulfurase that liberates sulphur from cysteine for [Fe-S] cluster biosynthesis.26 |
| Nfs1 | Human homolog of NiFS; 2 forms: isoform a (cytosolic) and isoform b (mitochondrial).2 |
| NiFU | Bacterial scaffold protein that provides foundation for the assembly of [2Fe-2S] and [4Fe-4S] clusters.28 |
| IscU | E coli NiFU homolog: scaffold protein involved in [4Fe-4S] cluster assembly.28 |
| Isu1, Isu2 | In yeast, IsU function is encompassed by Isu1 and Isu2.29 |
| Nfu1p | In yeast, Nfu1p functions in [Fe-S] cluster assembly in Isu1/2 or its insertion into an appropriate apoprotein.30,31 |
| IscU1, IscU2 | Human homologs of IscU; 2 forms: IscU1 (cytosolic) and IscU2 (mitochondrial). Both are scaffold proteins involved in [Fe-S] cluster assembly/disassembly.32 |
Protein . | Function . |
|---|---|
| NiFS | Azotobacter vinlandii cysteine desulfurase that liberates sulphur from cysteine for [Fe-S] cluster biosynthesis.26 |
| Nfs1 | Human homolog of NiFS; 2 forms: isoform a (cytosolic) and isoform b (mitochondrial).2 |
| NiFU | Bacterial scaffold protein that provides foundation for the assembly of [2Fe-2S] and [4Fe-4S] clusters.28 |
| IscU | E coli NiFU homolog: scaffold protein involved in [4Fe-4S] cluster assembly.28 |
| Isu1, Isu2 | In yeast, IsU function is encompassed by Isu1 and Isu2.29 |
| Nfu1p | In yeast, Nfu1p functions in [Fe-S] cluster assembly in Isu1/2 or its insertion into an appropriate apoprotein.30,31 |
| IscU1, IscU2 | Human homologs of IscU; 2 forms: IscU1 (cytosolic) and IscU2 (mitochondrial). Both are scaffold proteins involved in [Fe-S] cluster assembly/disassembly.32 |