Odds ratios for highest versus lowest quartile
Marker . | Patients N = 524‡ . | Crude OR . | OR adjusted for age and smoking . | Adjusted OR* . | OR for nonsmokers only, age corrected N = 617 . | OR adjusted for traditional risk factors and for time since the event . | Adjusted OR*for samples collected more than 2 years after the event N = 852 . | OR adjusted for traditional risk factors and for use of medication at time of sample collection . |
|---|---|---|---|---|---|---|---|---|
| MIF | 193 | 3.4 (2.3-4.9) | 3.1 (2.1-4.5) | 3.0 (2.0-4.4) | 5.2 (2.9-9.5) | 3.5 (2.3-5.2) | 2.0 (1.2-3.1) | 3.2 (2.1-4.9) |
| PI9 | 195 | 2.5 (1.8-3.5) | 2.5 (1.8-3.6) | 2.6 (1.8-3.8) | 3.1 (1.8-5.3) | 2.9 (2.0-4.2) | 2.0 (1.3-3.0) | 2.7 (1.8-4.1) |
| CCL3 | 183 | 2.2 (1.5-3.0) | 2.2 (1.5-3.1) | 2.3 (1.6-3.3) | 2.8 (1.7-4.6) | 2.3 (1.6-3.3) | 2.5 (1.6-3.8) | 2.4 (1.6-3.5) |
| PTPN1 | 170 | 2.3 (1.6-3.3) | 2.2 (1.5-3.2) | 2.2 (1.5-3.2) | 3.6 (2.1-6.2) | 2.5 (1.7-3.7) | 2.4 (1.5-3.8) | 2.2 (1.4-3.2) |
| BMI1 | 159 | 1.9 (1.3-2.7) | 1.8 (1.3-2.6) | 2.0 (1.4-2.9) | 1.7 (1.0-2.8) | 2.1 (1.4-3.0) | 1.9 (1.3-3.0) | 2.0 (1.3-3.0) |
| PDE4B | 162 | 1.9 (1.3-2.6) | 1.9 (1.3-2.7) | 1.9 (1.3-2.8) | 2.7 (1.6-4.6) | 2.2 (1.5-3.2) | 1.9 (1.2-2.9) | 1.9 (1.3-2.8) |
| GSTP1† | 162 | 1.9 (1.3-2.6) | 1.7 (1.2-2.4) | 1.8 (1.2-2.5) | 1.7 (1.0-2.8) | 1.6 (1.1-2.4) | 1.9 (1.2-2.9) | 1.9 (1.2-2.8) |
| NFKB1 | 182 | 2.0 (1.4-2.8) | 1.7 (1.2-2.5) | 1.7 (1.2-2.4) | 2.0 (1.2-3.3) | 1.8 (1.2-2.6) | 1.5 (1.0-2.3) | 1.4 (1.0-2.1) |
| IL12A | 165 | 1.8 (1.3-2.5) | 1.7 (1.2-2.5) | 1.7 (1.2-2.4) | 2.2 (1.3-3.6) | 1.7 (1.2-2.4) | 1.9 (1.3-3.0) | 1.6 (1.1-2.4) |
| PDGFB | 156 | 1.6 (1.1-2.2) | 1.6 (1.1-2.3) | 1.7 (1.2-2.4) | 1.3 (0.8-2.2) | 1.8 (1.2-2.6) | 1.5 (0.9-2.3) | 1.7 (1.2-2.6) |
| MYC | 182 | 2.0 (1.4-2.8) | 1.5 (1.1-2.2) | 1.6 (1.1-2.3) | 1.6 (1.0-2.6) | 1.5 (1.1-2.2) | 1.1 (0.7-1.7) | 1.4 (0.9-2.0) |
| IL1B | 193 | 2.0 (1.5-2.9) | 1.8 (1.2-2.5) | 1.6 (1.1-2.3) | 2.7 (1.6-4.5) | 1.6 (1.1-2.2) | 1.7 (1.1-2.6) | 1.7 (1.2-2.5) |
| IL8 | 152 | 1.6 (1.1-2.2) | 1.5 (1.1-2.1) | 1.6 (1.1-2.3) | 2.0 (1.2-3.3) | 1.7 (1.2-2.4) | 1.2 (0.8-1.9) | 1.6 (1.1-2.4) |
| NFKBIA | 174 | 1.7 (1.2-2.3) | 1.6 (1.1-2.2) | 1.5 (1.0-2.1) | 1.9 (1.2-3.1) | 1.4 (1.0-2.0) | 1.3 (0.9-2.0) | 1.6 (1.1-2.3) |
| IL15(1) | 140 | 1.4 (1.0-2.0) | 1.5 (1.0-2.1) | 1.5 (1.0-2.2) | 1.5 (0.9-2.6) | 1.5 (1.0-2.1) | 1.4 (0.9-2.1) | 1.3 (0.8-1.9) |
| LTA | 163 | 1.7 (1.2-2.3) | 1.3 (0.9-1.9) | 1.4 (1.0-2.0) | 1.4 (0.8-2.3) | 1.3 (0.9-2.0) | 1.4 (0.9-2.1) | 1.4 (1.0-2.1) |
| IFNG | 146 | 1.3 (0.9-1.8) | 1.4 (1.0-2.0) | 1.4 (1.0-2.1) | 1.5 (0.9-2.4) | 1.4 (1.0-2.0) | 1.4 (0.9-2.2) | 1.4 (1.0-2.1) |
| IL1RN | 160 | 1.7 (1.2-2.3) | 1.4 (1.0-2.0) | 1.3 (0.9-1.9) | 1.4 (0.8-2.3) | 1.3 (0.9-1.9) | 1.3 (0.8-1.9) | 1.1 (0.8-1.7) |
| TNFRSFIA | 153 | 1.4 (1.0-2.0) | 1.4 (1.0-1.9) | 1.3 (0.9-1.8) | 1.9 (1.2-3.1) | 1.3 (0.9-1.8) | 2.0 (1.3-3.0) | 1.2 (0.8-1.8) |
| IL18 | 134 | 1.3 (0.9-1.8) | 1.3 (0.9-1.8) | 1.3 (0.9-1.9) | 1.5 (0.9-2.4) | 1.3 (0.9-1.9) | 2.0 (1.3-3.2) | 1.3 (0.9-2.0) |
| CCL4 | 135 | 1.0 (0.7-1.4) | 1.2 (0.9-1.8) | 1.3 (0.9-1.9) | 0.9 (0.6-1.5) | 1.3 (0.9-1.8) | 1.5 (1.0-2.3) | 1.5 (1.0-2.2) |
| THBSI | 126 | 0.9 (0.6-1.2) | 0.9 (0.7-1.3) | 0.9 (0.6-1.3) | 0.7 (0.5-1.2) | 1.0 (0.7-1.4) | 1.2 (0.8-1.8) | 0.9 (0.6-1.4) |
| PARN | 117 | 0.8 (0.6-1.2) | 1.0 (0.7-1.4) | 1.0 (0.7-1.5) | 0.7 (0.4-1.1) | 1.0 (0.7-1.4) | 1.3 (0.8-1.9) | 1.0 (0.7-1.5) |
Marker . | Patients N = 524‡ . | Crude OR . | OR adjusted for age and smoking . | Adjusted OR* . | OR for nonsmokers only, age corrected N = 617 . | OR adjusted for traditional risk factors and for time since the event . | Adjusted OR*for samples collected more than 2 years after the event N = 852 . | OR adjusted for traditional risk factors and for use of medication at time of sample collection . |
|---|---|---|---|---|---|---|---|---|
| MIF | 193 | 3.4 (2.3-4.9) | 3.1 (2.1-4.5) | 3.0 (2.0-4.4) | 5.2 (2.9-9.5) | 3.5 (2.3-5.2) | 2.0 (1.2-3.1) | 3.2 (2.1-4.9) |
| PI9 | 195 | 2.5 (1.8-3.5) | 2.5 (1.8-3.6) | 2.6 (1.8-3.8) | 3.1 (1.8-5.3) | 2.9 (2.0-4.2) | 2.0 (1.3-3.0) | 2.7 (1.8-4.1) |
| CCL3 | 183 | 2.2 (1.5-3.0) | 2.2 (1.5-3.1) | 2.3 (1.6-3.3) | 2.8 (1.7-4.6) | 2.3 (1.6-3.3) | 2.5 (1.6-3.8) | 2.4 (1.6-3.5) |
| PTPN1 | 170 | 2.3 (1.6-3.3) | 2.2 (1.5-3.2) | 2.2 (1.5-3.2) | 3.6 (2.1-6.2) | 2.5 (1.7-3.7) | 2.4 (1.5-3.8) | 2.2 (1.4-3.2) |
| BMI1 | 159 | 1.9 (1.3-2.7) | 1.8 (1.3-2.6) | 2.0 (1.4-2.9) | 1.7 (1.0-2.8) | 2.1 (1.4-3.0) | 1.9 (1.3-3.0) | 2.0 (1.3-3.0) |
| PDE4B | 162 | 1.9 (1.3-2.6) | 1.9 (1.3-2.7) | 1.9 (1.3-2.8) | 2.7 (1.6-4.6) | 2.2 (1.5-3.2) | 1.9 (1.2-2.9) | 1.9 (1.3-2.8) |
| GSTP1† | 162 | 1.9 (1.3-2.6) | 1.7 (1.2-2.4) | 1.8 (1.2-2.5) | 1.7 (1.0-2.8) | 1.6 (1.1-2.4) | 1.9 (1.2-2.9) | 1.9 (1.2-2.8) |
| NFKB1 | 182 | 2.0 (1.4-2.8) | 1.7 (1.2-2.5) | 1.7 (1.2-2.4) | 2.0 (1.2-3.3) | 1.8 (1.2-2.6) | 1.5 (1.0-2.3) | 1.4 (1.0-2.1) |
| IL12A | 165 | 1.8 (1.3-2.5) | 1.7 (1.2-2.5) | 1.7 (1.2-2.4) | 2.2 (1.3-3.6) | 1.7 (1.2-2.4) | 1.9 (1.3-3.0) | 1.6 (1.1-2.4) |
| PDGFB | 156 | 1.6 (1.1-2.2) | 1.6 (1.1-2.3) | 1.7 (1.2-2.4) | 1.3 (0.8-2.2) | 1.8 (1.2-2.6) | 1.5 (0.9-2.3) | 1.7 (1.2-2.6) |
| MYC | 182 | 2.0 (1.4-2.8) | 1.5 (1.1-2.2) | 1.6 (1.1-2.3) | 1.6 (1.0-2.6) | 1.5 (1.1-2.2) | 1.1 (0.7-1.7) | 1.4 (0.9-2.0) |
| IL1B | 193 | 2.0 (1.5-2.9) | 1.8 (1.2-2.5) | 1.6 (1.1-2.3) | 2.7 (1.6-4.5) | 1.6 (1.1-2.2) | 1.7 (1.1-2.6) | 1.7 (1.2-2.5) |
| IL8 | 152 | 1.6 (1.1-2.2) | 1.5 (1.1-2.1) | 1.6 (1.1-2.3) | 2.0 (1.2-3.3) | 1.7 (1.2-2.4) | 1.2 (0.8-1.9) | 1.6 (1.1-2.4) |
| NFKBIA | 174 | 1.7 (1.2-2.3) | 1.6 (1.1-2.2) | 1.5 (1.0-2.1) | 1.9 (1.2-3.1) | 1.4 (1.0-2.0) | 1.3 (0.9-2.0) | 1.6 (1.1-2.3) |
| IL15(1) | 140 | 1.4 (1.0-2.0) | 1.5 (1.0-2.1) | 1.5 (1.0-2.2) | 1.5 (0.9-2.6) | 1.5 (1.0-2.1) | 1.4 (0.9-2.1) | 1.3 (0.8-1.9) |
| LTA | 163 | 1.7 (1.2-2.3) | 1.3 (0.9-1.9) | 1.4 (1.0-2.0) | 1.4 (0.8-2.3) | 1.3 (0.9-2.0) | 1.4 (0.9-2.1) | 1.4 (1.0-2.1) |
| IFNG | 146 | 1.3 (0.9-1.8) | 1.4 (1.0-2.0) | 1.4 (1.0-2.1) | 1.5 (0.9-2.4) | 1.4 (1.0-2.0) | 1.4 (0.9-2.2) | 1.4 (1.0-2.1) |
| IL1RN | 160 | 1.7 (1.2-2.3) | 1.4 (1.0-2.0) | 1.3 (0.9-1.9) | 1.4 (0.8-2.3) | 1.3 (0.9-1.9) | 1.3 (0.8-1.9) | 1.1 (0.8-1.7) |
| TNFRSFIA | 153 | 1.4 (1.0-2.0) | 1.4 (1.0-1.9) | 1.3 (0.9-1.8) | 1.9 (1.2-3.1) | 1.3 (0.9-1.8) | 2.0 (1.3-3.0) | 1.2 (0.8-1.8) |
| IL18 | 134 | 1.3 (0.9-1.8) | 1.3 (0.9-1.8) | 1.3 (0.9-1.9) | 1.5 (0.9-2.4) | 1.3 (0.9-1.9) | 2.0 (1.3-3.2) | 1.3 (0.9-2.0) |
| CCL4 | 135 | 1.0 (0.7-1.4) | 1.2 (0.9-1.8) | 1.3 (0.9-1.9) | 0.9 (0.6-1.5) | 1.3 (0.9-1.8) | 1.5 (1.0-2.3) | 1.5 (1.0-2.2) |
| THBSI | 126 | 0.9 (0.6-1.2) | 0.9 (0.7-1.3) | 0.9 (0.6-1.3) | 0.7 (0.5-1.2) | 1.0 (0.7-1.4) | 1.2 (0.8-1.8) | 0.9 (0.6-1.4) |
| PARN | 117 | 0.8 (0.6-1.2) | 1.0 (0.7-1.4) | 1.0 (0.7-1.5) | 0.7 (0.4-1.1) | 1.0 (0.7-1.4) | 1.3 (0.8-1.9) | 1.0 (0.7-1.5) |
Number of cases in the highest quartiles are shown in column 2. Results of a stratified analysis on men who were nonsmokers both at the index data and the sampling date are shown in column 6 after adjustment for age. Subsequent columns show odds ratios adjusted for traditional risk factors and for time since the event (column 7), adjusted odds ratios using only samples collected more than 2 years after the event (column 8), and adjustment for use of medication at time of sample collection (last column). 95% confidence intervals are shown in parentheses.
Adjusted for age, smoking, use of medication for hypertension and hypercholesterolemia, diabetes, BMI, alcohol habit, and quartile of CRP.
Out of 518 cases and 597 controls.
The number of controls in each quartile is 157 except for GSTP1. These numbers apply when restrictions are not used.