Table 1.

Clinical outcome in SCD patients included for standard criteria before and during therapy

Duration of hydroxyurea therapy
Before
1 y
2 y
3 y
4 y
5 y
6 y
7 y
8 y
No. of evaluable patients   109   106   88   70   54   39   32   24   14  
Hospitalizations per patient per year   3.2 ± 2.7   1.3 ± 2.2*  1.6 ± 2.9*  1.1 ± 1.5*  1.3 ± 1.9*  1.3 ± 1.5*  1.6 ± 1.7†  1.0 ± 1.3*  0.6 ± 1.2† 
Days in hospital per patient per year   20 ± 17   6.8 ± 14*  7.1 ± 12*  5.7 ± 8.5*  7.9 ± 11†  7.7 ± 9.6†  10 ± 13†  6.7 ± 8.3†  3.7 ± 7.0† 
Mean hydroxyurea dose, mg/kg daily, no.‡          
    Less than 20   NA   52   47   40   30   23   19   10   8  
    Between 20 to 25   NA   49   33   21   18   12   7   11   4  
    Between 25 to 30   NA   2   8   7   4   3   5   2   1  
    More than 30
 		 NA
 		 1
 		 1
 		 1
 		 2
 		 1
 		 1
 		 1
 		 0
 
Duration of hydroxyurea therapy
Before
1 y
2 y
3 y
4 y
5 y
6 y
7 y
8 y
No. of evaluable patients   109   106   88   70   54   39   32   24   14  
Hospitalizations per patient per year   3.2 ± 2.7   1.3 ± 2.2*  1.6 ± 2.9*  1.1 ± 1.5*  1.3 ± 1.9*  1.3 ± 1.5*  1.6 ± 1.7†  1.0 ± 1.3*  0.6 ± 1.2† 
Days in hospital per patient per year   20 ± 17   6.8 ± 14*  7.1 ± 12*  5.7 ± 8.5*  7.9 ± 11†  7.7 ± 9.6†  10 ± 13†  6.7 ± 8.3†  3.7 ± 7.0† 
Mean hydroxyurea dose, mg/kg daily, no.‡          
    Less than 20   NA   52   47   40   30   23   19   10   8  
    Between 20 to 25   NA   49   33   21   18   12   7   11   4  
    Between 25 to 30   NA   2   8   7   4   3   5   2   1  
    More than 30
 		 NA
 		 1
 		 1
 		 1
 		 2
 		 1
 		 1
 		 1
 		 0
 

Results are mean ± 1 SD. NA indicates not applicable.

*

Statistically significant change from baseline, defined by P < .001.

†

Statistically significant change from baseline, defined by P < .05.

‡

Data missing for 4 patient-years.

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