Cumulative event numbers and rates during an 8-year follow-up for 109 patients enrolled for standard criteria during 426 patient-years
Type of event . | Adverse events, n . | Rate/100 patient-years* . |
|---|---|---|
| Hospitalizations, no. | 587 | 138 |
| Hospitalization, d | 4400 | 1033 |
| Vaso-occlusive crisis requiring hospitalization, 2 or more than 2/y | 93 | 22 |
| Acute chest syndrome | 14 | 3.3 |
| Cerebrovascular event | 6* | 1.3 |
| Osteonecrosis | 5 | 1.1 |
| Priapism | 1 | 0.23 |
| Opportunistic infection | 0 | 0 |
| Transient hematologic toxicity | 6 | 1.4 |
| Death | 1 | 0.23 |
| Malignancy | 1 | 0.23 |
Type of event . | Adverse events, n . | Rate/100 patient-years* . |
|---|---|---|
| Hospitalizations, no. | 587 | 138 |
| Hospitalization, d | 4400 | 1033 |
| Vaso-occlusive crisis requiring hospitalization, 2 or more than 2/y | 93 | 22 |
| Acute chest syndrome | 14 | 3.3 |
| Cerebrovascular event | 6* | 1.3 |
| Osteonecrosis | 5 | 1.1 |
| Priapism | 1 | 0.23 |
| Opportunistic infection | 0 | 0 |
| Transient hematologic toxicity | 6 | 1.4 |
| Death | 1 | 0.23 |
| Malignancy | 1 | 0.23 |
There was 1 stroke and 5 TIAs. The patient who had stroke on HU had had initial stroke. The 5 TIA occurred in patients without any previous central nervous system (CNS) symptoms.